aml — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6S1435	Notopterol		Apoptosis , Others
	1. Notopterol induces apoptosis and inhibits cell cycle-specific.		Apoptosis , Others
T13950	UC-514321		Apoptosis , STAT
	UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.		Apoptosis , STAT
T15235	Enocitabine		Nucleoside Antimetabolite/Analog , HCV Protease , DNA/RNA Synthesis
	Enocitabine is a nucleoside analog. Enocitabine inhibits the replication of human cytomegalovirus(HCMV) and it also has antileukemic and antiviral activities. Enocitabine is also a potent DNA replication inhibitor and a ...
T13186	TL02-59		Apoptosis , Src , Hck
	TL02-59 is a selective inhibitor of Fgr in Src-family kinase (IC50 = 0.03 nM). TL02-59 inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. TL02-59 potently suppresses acute myelogenous leukemia cell growt...		Apoptosis , Src , Hck
T7138	FB23-2		Apoptosis , Others
	FB23-2 is a potent and selective mRNA N6-methyladenosine (m6A) demethylase FTO inhibitor(IC50 : 2.6 μM).		Apoptosis , Others
T12253	Nrf2-IN-1		Others , Nrf2
	Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).		Others , Nrf2
T12943	SNDX-5613		Epigenetic Reader Domain , Histone Methyltransferase
	SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias.		Epigenetic Reader Domain , Histone Methyltransferase
T9041	AES-350		Apoptosis , HDAC
	AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, ...		Apoptosis , HDAC
T13774	ML390		Others , Dehydrogenase
	ML390 exerts its potent differentiation effect on multiple leukemia models.		Others , Dehydrogenase
T16766	Ro 08-2750
	Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 µM. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM. Ro 08-2...
T6255	Bromosporine		Epigenetic Reader Domain , CDK
	Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.		Epigenetic Reader Domain , CDK
T3196	GNF-7	GNF7	Bcr-Abl , ACK , AChR
	GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.		Bcr-Abl , ACK , AChR
T5104	BTSA1		Apoptosis , BCL
	BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.		Apoptosis , BCL
T12575	Unesbulin	PTC596	Apoptosis , BMI-1
	Unesbulin (PTC596) is an orally active and selective inhibitor of B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1).		Apoptosis , BMI-1
T2099	ABT-737		Mitophagy , BCL , Autophagy
	ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).		Mitophagy , BCL , Autophagy
T16557	PNU-159682		Topoisomerase
	PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin. PNU-159682 has outstanding cytotoxicity. PNU-159682 is an effective ADCs cytotoxin.		Topoisomerase
T14919	CDKI-73		Apoptosis , CDK
	CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effe...		Apoptosis , CDK
T12148	N-Desmethyltamoxifen hydrochloride		Estrogen Receptor/ERR , Endogenous Metabolite , PKC
	N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.		Estrogen Receptor/ERR , Endogenous Metabolite , PKC
T38562	AKN-028		FLT
	AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.		FLT
T4570	Pipobroman	Vercyte,A-8103,Amedel	Others , DNA Alkylator/Crosslinker
	Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Pipobroman allows, wit...		Others , DNA Alkylator/Crosslinker