Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 85.00 | |
5 mg | In stock | $ 198.00 | |
10 mg | In stock | $ 376.00 | |
25 mg | In stock | $ 637.00 | |
50 mg | In stock | $ 888.00 | |
100 mg | In stock | $ 1,230.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 229.00 |
Description | UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity. |
In vitro | UC-514321 (0-500 nM, 48 h) inhibits AML cells viability TET1-signaling dependently.UC-514321 increases apoptosis in AML cells not in normal HSPCs. |
In vivo | In AML mice models, UC-514321 (2.5 mg/kg, i.p., once per day, for 10 days) exhibits more potent anti-tumor activity than NSC370284. |
Molecular Weight | 441.56 |
Formula | C26H35NO5 |
CAS No. | 299420-83-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (55.62 mM), sonification is recommended.
H2O: 50 mg/mL (113.23 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
UC-514321 299420-83-0 Apoptosis JAK/STAT signaling Stem Cells STAT AML myeloid UC 514321 low toxicity acute leukemia inhibit UC514321 Inhibitor inhibitor