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Enocitabine

Catalog No. T15235 CAS 55726-47-1

Enocitabine is a nucleoside analog. Enocitabine inhibits the replication of human cytomegalovirus(HCMV) and it also has antileukemic and <a href="/target/Antiviral" style="display: inline; color: #c13a36">Antiviral</a> activities. Enocitabine is also a potent <a href="/target/DNA" style="display: inline; color: #c13a36">DNA</a> replication inhibitor and a <a href="/target/DNA" style="display: inline; color: #c13a36">DNA</a> chain terminator.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Enocitabine, CAS 55726-47-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 178.00
5 mg	In stock	$ 365.00
10 mg	In stock	$ 617.00
25 mg	In stock	$ 1,111.00
50 mg	In stock	$ 1,667.00
100 mg	In stock	$ 2,498.00

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Purity: 98.02%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Enocitabine is a nucleoside analog. Enocitabine inhibits the replication of human cytomegalovirus(HCMV) and it also has antileukemic and antiviral activities. Enocitabine is also a potent DNA replication inhibitor and a DNA chain terminator.

In vitro

The combined effects of Pirarubicin and Enocitabine on HeLa S3 human uterine cervix carcinoma and K562 human myelocytic leukemia cells are determined by enhancement of their cytotoxic activities. Enocitabine or etoposide shows synergistic effects on HeLa S3 and K562 cells [2]. In the presence of Enocitabine, triphosphate forms of the nucleoside analogs are detected in the human cytomegalovirus (HCMV)-infected cells, and synthesis of HCMV DNA is strongly suppressed [3].

Molecular Weight	565.78
Formula	C31H55N3O6
CAS No.	55726-47-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 2 mg/mL (3.53 mM), Need ultrasonic and warming and heat to 60°C

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Hamada A, et al. Clinical pharmacokinetics of cytarabine formulations.Clin Pharmacokinet. 2002;41(10):705-18. 2. Nagasawa M, et al.In vitro combined effects of pirarubicin (THP) and various antitumor drugs on human tumor cell lines. Gan To Kagaku Ryoho. 1990 Apr;17(4 Pt 1):633-8. 3. Nakamura K, et al. Antiviral effect of antileukemic drugs N4-behenoyl-1-beta-D-arabinofuranosylcytosine (BH-AC) and 2,2'-anhydro-1-beta-D-arabinofuranosylcytosine (cyclo-C) against human cytomegalovirus. J Med Virol. 1990 Jun;31(2):141-7.

Related compound libraries

This product is contained In the following compound libraries：

FDA-Approved & Pharmacopeia Drug Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Compound Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Nucleotide Compound Library Inhibitor Library Bioactive Compounds Library Max Approved Drug Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Enocitabine 55726-47-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Proteases/Proteasome HCV Protease Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Inhibitor CMV inhibit Sunrabin Cytomegalovirus AML acute myelogenous leukaemia inhibitor

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