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Cat No. | Product Name | Synonyms | Targets |
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T39678 | Multitarget AD inhibitor-1 | ||
Multitarget AD inhibitor-1 is a reversible and selective inhibitor of butyrylcholinesterase (BuChE) with IC50 values of 7.22 μM and 1.55 μM for human BuChE (hBuChE) and equine serum BuChE (eqBuChE), respectively. Additio... | |||
T60150 | (1S,2R)-Alicapistat | Cysteine Protease | |
(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, with promising implications for Alzheimer's disease (AD) therapy [1]. This compound ef... | |||
T77042 | Aducanumab | BIIB037 | Beta Amyloid |
Aducanumab (BIIB037), A selective human immunoglobulin gamma-1 (IgG1) monoclonal antibody, targets the clustered form of amyloid beta (Aβ). Aducanumab shows brain permeability and may be used to treat Alzheimer's disease... | |||
T80622 | Trontinemab | ||
Trontinemab, a bispecific humanized IgG1-κ antibody, targets the amyloid beta A4 precursor protein (APP) and transferrin receptor p90, CD71 (TFRC). It is utilized in research on Alzheimer's disease (AD) [1] [2]. | |||
T4364 | Aftin-4 | Aftin 4,Aftin4 | Beta Amyloid , Gamma-secretase |
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus... | |||
T11175 | Elenbecestat | E2609 | Beta-Secretase , BACE |
Elenbecestat (E2609) is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease. | |||
TP1930L1 | Spexin acetate(1370290-58-6 free base) | Neuropeptide Y Receptor | |
Spexin acetate is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits... | |||
T76738 | Bapineuzumab | ||
Bapineuzumab, an anti-β-amyloid protein (APP) monoclonal antibody, is utilized in Alzheimer’s disease (AD) research [1]. | |||
T14178 | Alicapistat | ABT-957 | Others |
Alicapistat (ABT-957) is a human calpains 1 and 2 inhibitor. It can potentially be used to treat Alzheimer's disease (AD). | |||
T32330 | JWB1-84-1 3HCl | JWB1 84 1 3HCl,JWB1 84 1 trihydrochloride,JWB1-84-1 trihydrochloride,JWB1841 trihydrochloride | |
JWB1-84-1 3HCl, as a neuroprotective agent, can act by improving cognitive performances in a transgenic mouse model of AD. | |||
T80878 | Vanutide cridificar | PF 05236806,ACC-001 | |
Vanutide cridificar (ACC-001) is an aminoterminal Aβ1-7 peptide conjugate, employed in Alzheimer’s disease (AD) research [1]. | |||
T78807 | YIAD-0205 | ||
YIAD-0205, an orally administered inhibitor of Aβ(1-42) aggregation, has exhibited in vivo efficacy in a 5XFAD transgenic mouse model that harbors five familial AD mutations [1]. | |||
T76926 | Bepranemab | ||
Bepranemab (UCB 0107), a humanized full-length IgG4 monoclonal antibody, targets the central tau epitope (amino acids 235-250) and is utilized in Alzheimer’s disease (AD) research [1]. | |||
T79752 | DDC 2′,3′-O-disulfate | ||
DDC 2′,3′-O-disulfate (compound 4) inhibits the fibrillization and oligomerization of Aβ42, showing promise for Alzheimer's disease (AD) research [1]. | |||
T78333 | Rocatinlimab | AMG 451,KHK4083 | |
Rocatinlimab (AMG 451) (KHK4083) is a fully human, non-fucosylated IgG1 anti-OX40 monoclonal antibody indicated for atopic dermatitis (AD) research [1]. | |||
T76816 | Lokivetmab | ||
Lokivetmab, an Anti-Canine IL31 Recombinant Antibody, is a monoclonal antibody targeting canine IL-31, utilized in research related to atopic dermatitis (AD) in dogs [1]. | |||
T35892 | Q134R | Q134R | |
Q134R, a neuroprotective derivative of hydroxyquinoline, effectively inhibits nuclear factor of activated T-cell (NFAT) signaling and possesses the ability to cross the blood-brain barrier. This compound shows promise fo... | |||
T79010 | Lp-PLA2-IN-12 | Phospholipase | |
Lp-PLA2-IN-12 (compound 19), an Lp-PLA2 inhibitor, is utilized in researching neurodegenerative diseases including Alzheimer's disease (AD), glaucoma, age-related macular degeneration (AMD), and cardiovascular conditions... | |||
T80700 | β Amyloid(17-28) human | ||
β-Amyloid(17-28) human is a fragment of the β-amyloid peptide (Abeta) associated with Alzheimer's disease (AD), promoting the aggregation of the full-length β-Amyloid40 into toxic aggregates [1]. This lipid-induced amylo... | |||
T62578 | BuChE-IN-1 | ||
BuChE-IN-1 (Compound 23) is a potent, highly blood-brain barrier-permeable, low cytotoxicity inhibitor of butyrylcholinesterase (BuChE). BuChE-IN-1 is a BuChE inhibitor that has the potential to be used in the study of A... | |||
T61408 | BChE-IN-2 | ||
BChE-IN-2 (compound 22) is a highly effective inhibitor of BChE, exhibiting a Ki value of 0.099 μM. This compound represents a promising pyrimidine and pyridine derivative for investigating Alzheimer's disease (AD). [1] | |||
T79011 | TrkB-IN-1 | Trk receptor | |
TrkB-IN-1 is a potent, orally active agonist of the TrkB receptor, with favorable pharmacokinetic (PK) properties. It has been shown to reverse cognitive deficits in an Alzheimer's disease (AD) mouse model, thus serving ... | |||
T64181 | SEH/AChE-IN-1 | ||
sEH/AChE-IN-1 (Compound 12a) is a dual inhibitor of soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). sEH/AChE-IN-1 has a cumulative effect against neuroinflammation and memory impairment. sEH/AChE-IN-1 ha... | |||
T64214 | NXPZ-2 | ||
NXPZ-2 is an orally active Keap1-Nrf2protein-protein interaction (PPI) inhibitor (Ki: 95 nM, EC50: 120 and 170 nM). NXPZ-2 dose-dependently attenuates Aβ[1-42]-induced cognitive disturbances, enhances neuronal number and... | |||
T75930 | β-Amyloid (1-43)(human) TFA | ||
β-Amyloid (1-43)(human) TFA exhibits greater aggregation tendencies and heightened toxicity compared to its well-established counterpart, Aβ1-42. Additionally, this compound demonstrates associations with both sAPPα and ... | |||
T77028 | Gosuranemab | ||
Gosuranemab (BMS-986168), a humanized IgG4 anti-tau monoclonal antibody, specifically targets human N-terminal tau residues 15-22. It holds potential for Alzheimer’s disease (AD) research [1] [2]. | |||
T76395 | (Met(O)35)-Amyloid β-Protein (1-42) | ||
(Met(O)35)-Amyloid β-Protein (1-42) represents the oxidized form of Methionine 35 in Aβ42, capable of producing an oligomer size distribution akin to that of Aβ40. This compound is utilized in Alzheimer’s disease (AD) re... | |||
T62719 | AChE/BACE1/GSK3β-IN-1 | ||
AChE/BACE1/GSK3β-IN-1 is an orally active, blood-brain barrier-transparent, moderately bioavailable triple inhibitor of AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 can be used to study Alzheimer's disease (AD). | |||
T60739 | Y13g | ||
Y13g is the potent inhibitor of Interleukin-6 (IL-6) and acetylcholinesterase(AChE) which are two important targets implicated in Alzheimer's Disease(AD) progression. Y13g reverses the memory deficit induced by STZ as we... | |||
TP1228 | β-Amyloid (1-16) | Amyloid β-Protein (1-16),β-Amyloid 1-16 | |
β-Amyloid (1-16) is an amyloidogenic protein fragment with a sequence derived from β-amyloid. It exhibits the ability to bind to metal ions, indicating its involvement in metal-binding processes. β-Amyloid, a peptide, is... | |||
T78874 | GSK-3β inhibitor 15 | ||
GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-induced iNOS expression. It demonstrates neuroprotective propert... | |||
T79684 | 5-HT6R antagonist 1 | 5-HT Receptor | |
Compound 8 (5-HT6R antagonist 1), a 5-HT6R antagonist (K i : 5 nM), not only demonstrates inhibition of platelet aggregation and excellent metabolic stability but also reverses MK-801-induced memory impairments in rats, ... | |||
T79548 | AChE/BChE-IN-13 | ||
AChE/BChE-IN-13 (compound 5j) serves as a potent dual inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting half-maximal inhibitory concentrations (IC50) of 20.89 μM for AChE and 17.3... | |||
T79533 | PDE5-IN-10 | ||
PDE5-IN-10 (compound 4b), a potent phosphodiesterase type 5 (PDE5) inhibitor, exhibits an effective half-maximal inhibitory concentration (IC50) of 20 nM, enhanced in vitro microsomal stability (t 1/2 = 44.6 min), and ex... | |||
T61388 | HAChE/Aβ1-42-IN-1 | ||
Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and excellent brain-blood barrier (BBB) penetration with a broad sa... | |||
T76372 | TRAF6 peptide | ||
TRAF6 peptide, a specific TRAF6-p62 inhibitor, effectively inhibits NGF-dependent TrkA ubiquitination, showcasing strong research potential for neurological conditions including Alzheimer's disease (AD), Parkinson's, ALS... | |||
T80118 | α-Synuclein (61-95) (human) | ||
α-Synuclein (61-95) (human) constitutes the hydrophobic core of α-synuclein and is implicated in inducing neuronal cell death. This segment is utilized in the study of neurodegenerative conditions such as Alzheimer's dis... | |||
T61342 | BChE-IN-13 | ||
BChE-IN-13 (Compound 17c) is an orally active, potent, and selective inhibitor of Butyrylcholinesterase (BChE). It exhibits IC50 values of 0.22 μM and 0.016 μM for eqBChE and hBChE, respectively. BChE-IN-13 demonstrates ... | |||
T61785 | BChE-IN-6 | ||
BChE-IN-6 (compound 12) is a highly effective inhibitor of BChE, showcasing a Ki value of 0.182 μM. Notably, BChE-IN-6 exhibits significant chelating abilities towards Zn 2+. Due to these characteristics, BChE-IN-6 serve... | |||
T78221 | TRAF6 peptide TFA | E1/E2/E3 Enzyme | |
TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA. This peptide demonstrates promising research applications in various neurological disorde... | |||
T74818 | JNK3 inhibitor-8 | ||
JNK3 Inhibitor-8 is a potent, selective, and orally active inhibitor that can cross the blood-brain barrier, targeting JNK3 with IC50 values of 21 nM for JNK3, 2203 nM for JNK2, and >10000 nM for JNK1. This compound demo... | |||
T38002 | LEO 39652 | ||
LEO 39652, a dual-soft PDE4 inhibitor, demonstrates potent inhibition of PDE4 subtypes A, B, C, and D with respective IC50 values of 1.2 nM, 1.2 nM, 3.0 nM, and 3.8 nM. Additionally, it inhibits TNF-α with an IC50 of 6.0... | |||
T61087 | THK-5105 | ||
THK-5105, an arylquinoline derivative, demonstrates a high binding affinity for tau fibrils, protein aggregates, and tau-rich Alzheimer's disease (AD) brain homogenates, indicative of its potential as a tau imaging PET (... | |||
T76394 | Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42) | ||
Amyloid β-Protein (36-42), the 36-42 fragment of β-Amyloid, consists of a polypeptide chain of 36-43 amino acids and is a primary constituent of amyloid plaques in Alzheimer's disease (AD) patients' brains. β-Amyloid oli... | |||
T78596 | CAD031 | ||
CAD031, a more active derivative of the Alzheimer's disease (AD) targeting agent J147, exhibits neuroprotective and memory-enhancing properties. It has been shown to enhance memory, improve dendritic structure, and stimu... | |||
T82242 | HAChE-IN-6 | ||
hAChE-IN-6 (compound 51) is a brain-penetrant acetylcholinesterase (AChE) inhibitor exhibiting an IC50 of 0.16 μM. It also demonstrates inhibitory effects on human butyrylcholinesterase (hBuChE) and glycogen synthase kin... | |||
T75730 | [D-Arg25]-Neuropeptide Y (human) | ||
[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY), a Y1 receptor selective agonist, plays a role in Alzheimer's disease (AD) and safeguards rat cortical neurons from β-Amyloid toxicity [1]. | |||
T60907 | THK-5117 | ||
THK-5117 is an arylquinoline derivative with the potential as a PET probe for tau imaging. THK-5117 shows high binding affinity to tau fibrils with a Ki value of 10.5 nM. THK-5117 also shows high binding affinity to tau ... | |||
T76221 | Leptin (116-130) | ||
Leptin (116-130), a bioactive fragment of leptin, enhances synaptic plasticity in the hippocampus by promoting AMPA receptor trafficking to synapses. It preserves hippocampal synapse integrity and prevents neuronal cell ... | |||
T37148 | TML-6 | ||
TML-6, an oral curcumin derivative, demonstrates inhibitory effects on the synthesis of β-amyloid precursor protein and β-amyloid (Aβ). Additionally, TML-6 exhibits upregulation of Apo E, suppression of NF-κB and mTOR, a... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6S0721 | Orientin | Lutexin,Luteolin-8-glucoside | Others |
1. Orientin (Luteolin-8-glucoside) may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. 2. Orientin protects vascular barrier int... | |||
TN3218 | 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one | Beta Amyloid , PI3K , mTOR | |
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of Alzheimer's dise... | |||
T75544 | AChE/BChE-IN-11 | ||
AChE/BChE-IN-11 (compound 1), a natural product derived from artichoke leaves, is a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 70 μM for AChE and 71 μM for BChE, re... | |||
T75511 | BChE-IN-10 | ||
BChE-IN-10 (compound 6), isolated from Bletilla striata, is a potent mixed-type butyrylcholinesterase (BChE) inhibitor exhibiting an IC50 value of 6.4 μM. It is utilized in Alzheimer's disease (AD) research [1]. | |||
T75512 | Bleformin A | ||
Bleformin A, a natural product isolated from Bletilla striata, serves as a potent butyrylcholinesterase (BChE) inhibitor, exhibiting an IC50 value of 5.2 μM. It is utilized in Alzheimer's disease (AD) research [1]. | |||
T75514 | Blestrin D | ||
Blestrin D, a potent mixed-type butyrylcholinesterase (BChE) inhibitor with an IC50 value of 8.1 μM, is isolated from Bletilla striata and has applications in Alzheimer's disease (AD) research [1]. | |||
T75513 | BChE-IN-12 | ||
BChE-IN-12, also known as compound 12, is a potent non-competitive inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 2.3 μM. Derived from Bletilla striata, it is utilised in research related to Alzheimer's ... | |||
T75628 | Methyl ganoderate A acetonide | ||
Methyl ganoderate A acetonide, a lanostane triterpene derived from the fruiting bodies of Ganoderma lucidum, serves as a potent acetylcholinesterase (AChE) inhibitor with an IC50 value of 18.35 μM. Its efficacy in inhibi... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01284 | METTL11A Protein, Human, Recombinant (GST) | Human | E. coli |
Methyltransferase-like protein 11A, also known as METTL11A, is a member of the methyltransferase superfamily and METTL11 family. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a don... | |||
TMPY-04770 | RIOK1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
RIOK1, also known as RIO kinase 1, is a member of the RIO family of atypical serine protein kinases first characterized in yeast. RIOK1 and RIOK2 proteins are present in organisms from Archaea to humans. RIOK1 functions ... | |||
TMPY-01285 | METTL11A Protein, Human, Recombinant | Human | E. coli |
Methyltransferase-like protein 11A, also known as METTL11A, is a member of the methyltransferase superfamily and METTL11 family. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a don... | |||
TMPY-01479 | SPG3A Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
Atlastin-1, also known as Spastic paraplegia 3 protein A, Guanine nucleotide-binding protein 3, GTP-binding protein 3, GBP3, ATL1 and SPG3A, is a multi-pass membrane protein which belongs to theGBP family and atlastin... | |||
TMPJ-00023 | SNCA Protein, Human, Recombinant (His) | Human | E. coli |
Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1, Phospholipase D and hist... | |||
TMPY-00668 | APP/Protease nexin-II Protein, Human, Recombinant (hFc) | Human | HEK293 |
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can... | |||
TMPY-02110 | Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST) | Human | E. coli |
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can... | |||
TMPY-02221 | Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST) | Human | E. coli |
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can... | |||
TMPY-03884 | Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST) | Human | E. coli |
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can... | |||
TMPY-03885 | Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST) | Human | E. coli |
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can... | |||
TMPY-01253 | LAMP1 Protein, Human, Recombinant (His) | Human | HEK293 |
Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein that belongs to the LAMP family. CD107a is expressed largely in t... | |||
TMPH-02996 | KsdD Protein, Mycobacterium smegmatis, Recombinant (His & Myc) | Mycolicibacterium smegmatis | E. coli |
Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids. Is also involved in the formation of 1,4-androstadiene-3,17-dione (ADD) from 4-androstene-3,... | |||
TMPJ-00782 | Amyloid Precursor Protein, Human, Recombinant (hFc) | Human | Human Cells |
Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and... | |||
TMPY-01303 | Serpin A3 Protein, Human, Recombinant (His) | Human | HEK293 |
SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a plasma alpha globulin glycoprotein, and is a member of serpin superfamily of the serine protease inhibitors consisting of at least 35 members. SerpinA3 has be... | |||
TMPY-02916 | LAMP1 Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein that belongs to the LAMP family. CD107a is expressed largely in t... | |||
TMPY-03653 | CTRL Protein, Human, Recombinant (His) | Human | HEK293 |
CTRL-1, also known as chymotrypsin-like protease, belongs to thepeptidase S1 family. CTRL-1 contains 1peptidase S1 domain. Its expression is increased in preeclampsia (PE). Placental-derived chymotrypsin-like protease is... | |||
TMPY-02393 | Thimet Oligopeptidase/THOP1 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
THOP1, also known as Thimet oligopeptidase 1, Thimet oligopeptidase, EC 3.4.24.15, or EP24.15, is a zinc(II) endopeptidase implicated in the processing of numerous physiological peptides. As an intracellular enzyme, high... | |||
TMPY-00519 | Gastrokine 1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Gastrokine 1 (GKN1) belongs to the BRICHOS domain family and plays a major role in maintaining gastric mucosa integrity. GKN1 is highly expressed in gastric tissue and is secreted into the stomach but is not expressed in... | |||
TMPY-02300 | BIN1 Protein, Human, Recombinant (His) | Human | E. coli |
Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicat... | |||
TMPY-01297 | Nicastrin Protein, Human, Recombinant (His) | Human | HEK293 |
Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of th... | |||
TMPY-01221 | Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 |
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Le... | |||
TMPY-01056 | Nogo Receptor/RTN4R Protein, Human, Recombinant (His & hFc) | Human | HEK293 |
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Le... | |||
TMPY-03144 | Nogo Receptor/RTN4R Protein, Human, Recombinant (His) | Human | HEK293 |
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Le... | |||
TMPY-01163 | Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Le... | |||
TMPY-02910 | Nicastrin Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of th... | |||
TMPY-03074 | Nicastrin Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of th... | |||
TMPY-01233 | LRPAP1 Protein, Human, Recombinant (His) | Human | HEK293 |
Receptor-associated protein (RAP) is a molecular chaperone for low-density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is a... | |||
TMPY-04451 | AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus-Insect Cells | |||
TMPY-01732 | LRPAP1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Receptor-associated protein (RAP) is a molecular chaperone for low-density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is a... | |||
TMPY-03878 | Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) | Human | HEK293 |
Integrin alpha-5, also known as ITGA5, is a single-pass type I membrane protein which belongs to the integrin alpha chain family. ITGA5 contains 7 FG-GAP repeats. Alpha chain 5 undergoes post-translational cleavage in th... | |||
TMPY-02501 | CD3D & CD3E Heterodimer Protein, Human, Recombinant | Human | HEK293 |
CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 cells. | |||
TMPY-03745 | CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) | Human | HEK293 |
CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 with Flag and His tag. The predicted molecular weight is 31.05 kDa. Accession number: P04234-1&P07766-1 | |||
TMPY-02794 | TLR2 Protein, Human, Recombinant (aa 1-587, His) | Human | Baculovirus-Insect Cells |
TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathoge... | |||
TMPY-03947 | CD48 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. CD2 and 2B4 (CD244) are known ligands for CD4... | |||
TMPY-03481 | IL-1R2 Protein, Human, Recombinant | Human | HEK293 |
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interl... | |||
TMPK-00114 | C-Reactive Protein /CRP Protein, Human, Recombinant (His) | Human | HEK293 |
C-reactive protein (CRP) is a polypeptide molecule belonging to the family of pentraxins. CRP is synthesized primarily by the liver in response to certain pro-inflammatory cytokines. It plays an important role in innate ... | |||
TMPY-00740 | SDF-1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f... | |||
TMPY-04384 | Src Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C... | |||
TMPK-01151 | MXRA8 Protein, Human, Recombinant (His) | Human | HEK293 |
Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. | |||
TMPK-01074 | CD163 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in ... | |||
TMPK-00383 | ACE2/ACEH Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angio... | |||
TMPY-02525 | RGMA Protein, Human, Recombinant (His) | Human | HEK293 |
RGMa, also known as RGM domain family, member A, belongs to the RGM (repulsive guidance molecule) family whose members are membrane-associated glycoprotein. RGMa is a glycosylphosphatidylinositol-anchored glycoprotein th... | |||
TMPY-04753 | IRE1 Protein, Human, Recombinant (aa 465-977) | Human | Baculovirus-Insect Cells |
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ... | |||
TMPY-04413 | IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) | Human | Baculovirus-Insect Cells |
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ... | |||
TMPK-01393 | Tenascin Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates,... | |||
TMPK-00305 | TGFBR1 Protein, Human, Recombinant (mFc & Avi) | Human | HEK293 |
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup... | |||
TMPY-01460 | ABHD4 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Abhydrolase domain containing 4 (ABHD4), also known as alpha/beta-hydrolase 4 (ABH4) , or lyso-N-acylphosphatidylethanolamine lipase, which belongs to the ABHD4/ABHD5 subfamily of peptidase S33 family. Abhydrolase domain... | |||
TMPY-00978 | Progranulin Protein, Human, Recombinant (His) | Human | HEK293 |
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, ... | |||
TMPY-02227 | IL-1 beta/IL-1F2 Protein, Rat, Recombinant (mature form) | Rat | E. coli |
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair ... | |||
TMPY-05526 | Siglec-15 Protein, Human, Recombinant (His) | Human | HEK293 |
Siglec-15 Protein, Human, Recombinant (His) is expressed in HEK293 cells. | |||
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Cat No. | Product Name | ||
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L9840 | Anti-Alzheimer's Disease Compound Library | 986 compounds | |
A unique collection of 986 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS. |