a549 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2430	HPOB		Apoptosis , HDAC
	HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.		Apoptosis , HDAC
T6455	CP-91149		Phosphorylase
	CP-91149 is a selective glycogen phosphorylase (GP) inhibitor with IC50 of 0.13 μM in the presence of glucose, 5- to 10-fold less potent in the absence of glucose.		Phosphorylase
T9119	SU0268		Others
	SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.		Others
T15411	GPNA hydrochloride		Apoptosis , Others
	GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT)....		Apoptosis , Others
T8466	BC-DXI-843		Others
	BC-DXI-843 is inhibitor of AIMP2-DX2, and is potential for development of novel therapeutics targeting AIMP2-DX2 in lung cancer.		Others
T3870	Cyasterone	Cyasteron	Apoptosis , EGFR
	Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising anti-cancer agent. Cyasterone has antifeeding activity.		Apoptosis , EGFR
T11631	IFSP1		Ferroptosis
	iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RS...		Ferroptosis
T60028	MM41		DNA/RNA Synthesis
	MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line.		DNA/RNA Synthesis
T5739	Paederosidic acid		Apoptosis , BCL
	Paederosidic acid has significant anti-tumor, anticonvulsant and sedative effects. Paederosidic acid increases brain gamma-aminobutyric acid and decreases glutamic acid in the brain, and it up-regulates expressions of GA...		Apoptosis , BCL
T8793	CBS1117		Influenza Virus
	CBS1117 is a virus entry inhibitor (IC50 of 70 nM for influenza A virus, A/Puerto Rico/8/34 (H1N1)）. It interferes with the hemagglutinin (HA)-mediated fusion process.		Influenza Virus
T50005	Sertaconazole		Antifungal
	Sertaconazole is a broad-spectrum antifungal.		Antifungal
T7856	Naphthol AS-E	nAS-E	Epigenetic Reader Domain , Histone Acetyltransferase
	Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.		Epigenetic Reader Domain , Histone Acetyltransferase
T5758	Sphondin		COX , Prostaglandin Receptor
	Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.		COX , Prostaglandin Receptor
T1083	Theophylline	Theo-24,1,3-Dimethylxanthine	Endogenous Metabolite , HDAC , PDE , Adenosine Receptor , Autophagy
	Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3...
T8317	5'-Fluoroindirubinoxime	5'-FIO	FLT
	5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).		FLT
T16961	Supinoxin	RX-5902	Apoptosis , DNA/RNA Synthesis
	Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase and a potent first-in-class anti-cancer agent. Supinoxin induces cell apoptosis and inhibits the growth of TNBC cancer cell lines (IC50...		Apoptosis , DNA/RNA Synthesis
T7122	AZD-7648		DNA-PK
	AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.		DNA-PK
T9098	DMG-PEG 2000	DMG-PEG2000	Others
	DMG-PEG 2000 (DMG-PEG2000) is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles. Formulations containing DMG-PEG 2000 have been used in the development of lipid...		Others
T5S0106	Peimisine	Ebeiensine	RAAS , AChR
	1. Peimisine (Ebeiensine) can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. 2. Pe...		RAAS , AChR
T0239	Lonidamine	AF1890,DICA,Diclondazolic Acid	Apoptosis , Hexokinase , Mitochondrial Metabolism
	Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).		Apoptosis , Hexokinase , Mitochondrial Metabolism