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Lonidamine

Catalog No. T0239 CAS 50264-69-2

Synonyms: DICA, 氯尼达明, Diclondazolic Acid, AF1890

Lonidamine is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).

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Lonidamine, CAS 50264-69-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Lonidamine is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).
Targets&IC50	Mitochondrial pyruvate carrier:2.5 μM (Ki)

Synonyms	DICA, 氯尼达明, Diclondazolic Acid, AF1890
Molecular Weight	321.16
Formula	C15H10Cl2N2O2
CAS No.	50264-69-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 32.1 mg/mL (100 mM)

Ethanol: 1.6 mg/mL (5 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Floridi A, et al. J Natl Cancer Inst, 1981, 66(3), 497-499. 2. Belzacq AS, et al. Oncogene, 2001, 20(52), 7579-7587. 3. Ravagnan L, et al. Oncogene, 1999, 18(16), 2537-2546. 4. Del Bufalo D, et al. J Clin Invest, 1996, 98(5), 1165-1173. 5. Miccoli L, et al. J Natl Cancer Inst, 1998, 90(18), 1400-1406. 6. Guo L, et al. Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine. J Biol Chem. 2016 Jan 1;291(1):42-57. 7. Nancolas B, et al. The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters. Biochem J. 2016 Apr 1;473(7):929-36.

Citations

1. Chen C, Zhang X, Wang Y, et al. Translational and Post-translational Control of Human Naïve versus Primed Pluripotency. iScience. 2021: 103645.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Anti-Obesity Compound Library Mitochondria-Targeted Compound Library Anti-Metabolism Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Kinase Inhibitor Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lonidamine 50264-69-2 代谢凋亡 Apoptosis Hexokinase Mitochondrial Metabolism mitochondrial complex lactate lung fibrosis Mitochondrial Diclondazolic Acid A549 Inhibitor DICA AF-1890 H2030BrM3 inhibit AF1890 pulmonary fibrosis AF 1890 inhibitor

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