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Lonidamine

Name: Lonidamine
Brand: TargetMol
SKU: T0239
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0239Cas No. 50264-69-2

Alias Diclondazolic Acid, DICA, AF1890

Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).

Lonidamine

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Purity: 97.90%

Catalog No. T0239Alias Diclondazolic Acid, DICA, AF1890Cas No. 50264-69-2

Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).

Pack Size	Price	Availability
2 mg	$33	In Stock
5 mg	$45	In Stock
10 mg	$58	In Stock
25 mg	$75	In Stock
50 mg	$117	In Stock
100 mg	$152	In Stock
500 mg	$373	In Stock
1 g	$555	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Purity:97.90%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).
Targets&IC50	Mitochondrial pyruvate carrier:2.5 μM (Ki)
In vitro	In mice carrying glioma tumors, Lonidamine (160 mg/kg) effectively reduced tumor growth.
In vivo	In both normal and tumor cells, Lonidamine reduces oxygen consumption while augmenting aerobic glycolysis in normal cells, thereby inhibiting aerobic glycolysis in tumor cells. The compound induces apoptosis at a concentration of 50 mg/ml in resistant cell lines, including the human breast cancer cell line MCF-7 ADR(r) and the LB9 multiform glioblastoma cell line, which exhibit resistance to doxorubicin and nitrosourea.
Synonyms	Diclondazolic Acid, DICA, AF1890

Chemical Properties

Molecular Weight	321.16
Formula	C₁₅H₁₀Cl₂N₂O₂
Cas No.	50264-69-2
Smiles	OC(=O)c1nn(Cc2ccc(Cl)cc2Cl)c2ccccc12
Relative Density.	1.47 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (186.82 mM), Sonication is recommended.

Ethanol: 1.6 mg/mL (4.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1137 mL	15.5686 mL	31.1371 mL	155.6856 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.6227 mL	3.1137 mL	6.2274 mL	31.1371 mL
10 mM	0.3114 mL	1.5569 mL	3.1137 mL	15.5686 mL
20 mM	0.1557 mL	0.7784 mL	1.5569 mL	7.7843 mL
50 mM	0.0623 mL	0.3114 mL	0.6227 mL	3.1137 mL
100 mM	0.0311 mL	0.1557 mL	0.3114 mL	1.5569 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc