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SU0268

Catalog No. T9119 CAS 2210228-45-6

SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.

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SU0268, CAS 2210228-45-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 155.00
25 mg	In stock	$ 322.00
50 mg	In stock	$ 513.00
100 mg	In stock	$ 747.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 99.98%

Purity: 99.9%

Biological Description

Chemical Properties

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Description	SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.
In vitro	SU0268/IACS-4759 (5-20 μM, 48h) co-treated cells are more viable than the correspondingly-treated IACS-4759- or SU0268-treated cells[1]. MTH1-depleted cells are less sensitive to the OGG1-specific inhibitor, SU0268 (5-10 μM), compared to their control shGFP counterparts[1]. SU0268 does not bind DNA and thus interacts with OGG1 specifically rather than its substrate[2]. SU0268 induces the release of type I IFN by the mitochondrial DNA-cGAS-STING-IRF3-IFN-β axis, which decreases bacterial loads and halts disease progression[3].
In vivo	In MH-S cells and C57BL/6N mice, SU0268 pretreatment (10 mg/kg, intranasally treated) increases survival rates compared with controls without SU0268 pretreatment [3].

Molecular Weight	475.56
Formula	C26H25N3O4S
CAS No.	2210228-45-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (210.28 mM), Sonication is recommended.

References and Literature

1. Ling Zhang, et al. OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1. Redox Biol. 2021 Apr;40:101848. 2. Yu-Ki Tahara, et al. Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase. J Am Chem Soc. 2018 Feb 14;140(6):2105-2114. 3. Shugang Qin, et al. Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during Pseudomonas aeruginosa Infection. J Immunol. 2020 Oct 15;205(8):2231-2242.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Immunology/Inflammation Compound Library Anti-Infection Compound Library Bioactive Compound Library NO PAINS Compound Library Bioactive Compounds Library Max DNA Damage & Repair Compound Library

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Keywords

SU0268 2210228-45-6 Others MCF-7 Inhibitor cGAS OGG1 A549 STING SU 0268 IRF3 SU-0268 inhibit HeLa glycosylase antibacterial inhibitor

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