transformation — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6483	EHT 1864	EHT 1864 2HCl	Rho , Ras
	EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM).		Rho , Ras
T4060	Acelarin	NUC-1031	DNA/RNA Synthesis
	Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.		DNA/RNA Synthesis
T31425	Dibenz[a,h]anthracene	CCRIS 208,NSC 22433,AI3-18996,DB(a,h)A	DNA
	Dibenz[a,h]anthracene (CCRIS 208) has induced DNA damage and gene mutations in bacteria and gene mutations and transformation in several types of mammalian cell cultures.		DNA
T25284	DAC-2-25	DAC 225,DAC-225,DAC 2 25	Others
	DAC-2-25 is a Hydra head regeneration modulator. It acts by inducing a homeotic transformation in Hydra.		Others
T13166	TK216		Others , DNA/RNA Synthesis
	TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.		Others , DNA/RNA Synthesis
T2987	(-)-Epigallocatechin	l-Epigallocatechin,Epigallocatechin,EGC	MMP , Autophagy
	(-)-Epigallocatechin, the predominant flavonoid in green tea, possesses the unique ability to attach to unfolded native polypeptides, thereby inhibiting their transformation into amyloid fibrils.		MMP , Autophagy
T5983	O-Phenanthroline	1,10-Phenanthroline	MMP , Others
	o-Phenanthroline (1,10-Phenanthroline) , a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells.o-Phenanthroline protects mammalian cells from hydrogen peroxide-induced gene m...		MMP , Others
T33762	Fosifloxuridine nafalbenamide	NUC-3373,NUC3373,NUC 3373	DNA/RNA Synthesis
	Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. NUC-3373 has anticancer activity. NUC-3373 is a ProTide transformation of 5-FU that generates much higher c...		DNA/RNA Synthesis
T50110	CD532		Aurora Kinase
	CD532 is A highly potent Aurora A kinase inhibitor with an IC50 value of 45 nM. CD532 can block Aurora A kinase activity, drive MYCN degradation, and can directly interact with AURKA and induce global conformational tran...		Aurora Kinase
T3S1513	(20R)-Protopanaxadiol	Protopanaxadiol,20R-Protopanaxadiol,(20R)-Protopanaxdiol	Others , Antibacterial
	1. (20R)-Protopanaxadiol ((20R)-Protopanaxdiol) has the effect of anti-tumor through increasing the activity of body immunity, inhibiting tumor interstitial microvascular density and its proliferation activity, improving...		Others , Antibacterial
T6017	Linsitinib	OSI-906	IGF-1R
	OSI-906 (Linsitinib (OSI-906)) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, whic...		IGF-1R
T4703	(2-Aminoethyl)phosphonic acid	2-Aminoethylphosphonic acid,Ciliatine,2-AEP	Others , Endogenous Metabolite
	(2-Aminoethyl)phosphonic acid (2-Aminoethylphosphonic acid) is primarily detected in urine. (2-Aminoethyl)phosphonic acid participates in many enzymatic reactions and is also the parent compound of other transformation p...		Others , Endogenous Metabolite
TN2063	Physalin B	NSC-287088	Apoptosis , NF-κB , Akt , PI3K , Nrf2 , NOD
	Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammatory eczema and herpes, among other diseases.Physalin B amel...		Apoptosis , NF-κB , Akt , PI3K , Nrf2 , NOD
T5S0018	Betulonic acid	(+)-Betulonic acid,Betunolic acid,Liquidambaric acid	Parasite , HSV
	1. Betulonic acid (Liquidambaric acid) amide stimulated the regenerative response in hepatocytes under conditions of combined toxic exposure and promoted recovery of their qualitative and quantitative characteristics, wh...		Parasite , HSV
T4861	Trans-Aconitic acid		ATPase , Endogenous Metabolite
	Trans-Aconitic acid is normally present in normal human urine, and it has been suggested that is present in larger amounts with Reye's syndrome and organic aciduria. trans-Aconitic acid is a substrate of enzyme trans-aco...		ATPase , Endogenous Metabolite
T68405	KW-2450 free base		IGF-1R
	KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 free ...		IGF-1R
T4855	Tricosanoic acid	Tricosan-1-oic acid	Endogenous Metabolite
	Tricosanoic acid (Tricosan-1-oic acid) , also known as N-tricosanoate or tricosylate, belongs to the class of organic compounds known as very long-chain fatty acids.Tricosanoic acid has been detected in multiple biofluid...		Endogenous Metabolite
T3S0013	Ethyl trans-caffeate	Ethyl caffeate,Caffeic Acid Ethyl Ester	Others
	1. Ethyl trans-caffeate (Caffeic Acid Ethyl Ester) has anti-inflammatory activity. 2. Ethyl trans-caffeate may as a promising natural compound for future application in chronic liver disease. 3. Ethyl trans-caffeate is a...		Others
T4013	SGC2085 HCl		Histone Methyltransferase
	SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulat...		Histone Methyltransferase
T32464	L 685487	13-Desmethyl FR 900520,L685487,L-685487
	L 685487 is produced by microbial transformation of FR 900520.