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Acelarin

🥰Excellent
Catalog No. T4060Cas No. 840506-29-8
Alias NUC-1031

Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.

Acelarin

Acelarin

🥰Excellent
Purity: 99.26%
Catalog No. T4060Alias NUC-1031Cas No. 840506-29-8
Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$38In StockIn Stock
2 mg$54In StockIn Stock
5 mg$89In StockIn Stock
10 mg$147In StockIn Stock
25 mg$288In StockIn Stock
50 mg$442In StockIn Stock
100 mg$617In StockIn Stock
200 mg$873In Stock-
1 mL x 10 mM (in DMSO)$98In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.26%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.
Targets&IC50
DNA synthesis:EC50 : 0.2 nM
SynonymsNUC-1031
Chemical Properties
Molecular Weight580.47
FormulaC25H27F2N4O8P
Cas No.840506-29-8
SmilesFC1(F)[C@@H](O[C@H](COP(OC2=CC=CC=C2)(N[C@H](C(OCC3=CC=CC=C3)=O)C)=O)[C@H]1O)N4C(=O)N=C(N)C=C4
Relative Density.1.51 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (94.75 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.45 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7227 mL8.6137 mL17.2274 mL86.1371 mL
5 mM0.3445 mL1.7227 mL3.4455 mL17.2274 mL
10 mM0.1723 mL0.8614 mL1.7227 mL8.6137 mL
20 mM0.0861 mL0.4307 mL0.8614 mL4.3069 mL
50 mM0.0345 mL0.1723 mL0.3445 mL1.7227 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RNASynthesisRNA SynthesisNUC1031NUC 1031InhibitorinhibitDNASynthesisDNA/RNA SynthesisDNA SynthesisDNA synthesisAcelarin
Related Tags: buy Acelarin | purchase Acelarin | Acelarin cost | order Acelarin | Acelarin chemical structure | Acelarin formula | Acelarin molecular weight
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