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SGC2085 HCl

Catalog No. T4013 CAS 1821908-49-9

SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulator of Wnt/β-catenin transcription and neoplastic transformation in colorectal cancer as well as a critical factor in estrogen-stimulated breast cancer growth, and its depletion results in decreased proliferation of myeloid leukemia cells in vivo.

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SGC2085 HCl, CAS 1821908-49-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 85.00
2 mg	In stock	$ 153.00
5 mg	In stock	$ 200.00
10 mg	In stock	$ 361.00
25 mg	In stock	$ 597.00
50 mg	In stock	$ 868.00
100 mg	In stock	$ 1,190.00
1 mL * 10 mM (in DMSO)	In stock	$ 256.00

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Purity: 99.91%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

CARM1:50 nM

Molecular Weight	348.87
Formula	C19H24N2O2·HCl
CAS No.	1821908-49-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (157.65 mM)

References and Literature

1. Renato., et al. Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening . J Med Chem. 2016 Jul 28;59(14):6838-47.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Epigenetics Compound Library Reprogramming Compound Library Anti-Cancer Compound Library Histone Modification Compound Library Hematonosis Compound Library Anti-Aging Compound Library Bioactive Compound Library Stem Cell Differentiation Compound Library

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JQEZ5 SMYD3-IN-1 PRMT5-IN-31 EZH2-IN-15 SGC-iMLLT Igermetostat EBI-2511 UNC0379

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SGC2085 HCl 1821908-49-9 Chromatin/Epigenetic Histone Methyltransferase SGC-2085 HCl inhibitor inhibit

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