suppressor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP2281	P53 tumor suppressor fragment		Others
	p53 tumor suppressor fragment (232-240) is a peptide with the sequence H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH, MW= 1066.3. p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial ...		Others
TN1722	Hamamelitannin		Antifection
	Hamamelitannin has cytotoxic, and antibiofilm activities. It increases the susceptibility of S. aureus to antibiotic treatment in in vivo Caenorhabditis elegans and mouse mammary gland infection models. It also has a hig...		Antifection
T8497	SX-682		CXCR
	SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer.		CXCR
T16269	Nanaomycin A		DNA Methyltransferase , Dehydrogenase , Parasite
	Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).		DNA Methyltransferase , Dehydrogenase , Parasite
T4902	Isotrifoliin	Isoquercetin,Isoquercitroside	Reactive Oxygen Species
	Isotrifoliin (Isoquercitroside)n is an effective antioxidant and an eosinophilic inflammation suppressor.		Reactive Oxygen Species
T3184	Kevetrin hydrochloride	Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride	Mdm2 , p53
	Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.		Mdm2 , p53
T8967	SW155246		DNA Methyltransferase
	SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.		DNA Methyltransferase
T6696	Tazarotene	Tazorac,AGN 190168,Zorac	Retinoid Receptor , Autophagy
	Tazarotene (Zorac) is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiati...		Retinoid Receptor , Autophagy
T35362	NSC622608		Others
	NSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors.		Others
T31932	GJ071 oxalate	GJ 071,GJ-071,GJ071	Others
	GJ071 oxalate is a Nonsense suppressor. Nonsense suppressors (NonSups) induce “readthrough”, i.e., the selection of near cognate tRNAs at premature termination codons and insertion of the corresponding amino acid into na...		Others
T20533	NNK	Nicotine-derived nitrosamine ketone	Lipoxygenase
	NNK (Nicotine-derived nitrosamine ketone) is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.		Lipoxygenase
T10352	APTO-253	LOR-253,LT-253	Apoptosis , c-Myc , KLF
	APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through the induction of the K...		Apoptosis , c-Myc , KLF
T11631	IFSP1		Ferroptosis
	iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RS...		Ferroptosis
T83658	SQLE-IN-1		Antifungal
	SQLE-IN-1 is a squalene epoxidase (SQLE) inhibitor with anti-tumor activity. It can inhibit the proliferation and migration of liver cancer cell line Huh7, inhibit the production of cellular cholesterol, and increase the...		Antifungal
T9636	Dalpiciclib	SHR-6390	CDK
	Dalpiciclib (SHR-6390) is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respectively. Dalpiciclib exerts potent antitumor activity in esophag...		CDK
TP1345	Kisspeptin-10, human (TFA)(374675-21-5,FREE)		GPR , Kisspeptin
	Kisspeptin-10, human TFA is a potent vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role i...		GPR , Kisspeptin
T4717	25-Hydroxycholesterol		Others , Endogenous Metabolite , HMG-CoA Reductase
	25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regu...		Others , Endogenous Metabolite , HMG-CoA Reductase
T3661	Citarinostat	ACY241,HDAC-IN-2	HDAC
	ACY-241, also known as Citarinostat (ACY241), is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activ...		HDAC
T60013	GA-017		Others
	GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell prolifer...		Others
T64529	MDL-800	MDL 800,MDL800	Sirtuin
	MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.		Sirtuin