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Isotrifoliin

Catalog No. T4902   CAS 21637-25-2
Synonyms: Isoquercetin, Isoquercitroside

Isotrifoliin (Isoquercitroside)n is an effective antioxidant and an eosinophilic inflammation suppressor.

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Isotrifoliin Chemical Structure
Isotrifoliin, CAS 21637-25-2
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1 mL * 10 mM (in DMSO) In stock $ 43.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Isotrifoliin (Isoquercitroside)n is an effective antioxidant and an eosinophilic inflammation suppressor.
In vitro Isoquercitrin occurs widely in plants.10 μM of Isoquercitrin of the seven compounds partially but significantly blunt the negative effect of H2O2 on RGC-5 cells, as the viability of cells in the presence of H2O2 is increased from approximately 63% to 83% and 90% at 10 and 50 μM, respectively. Indeed, 50 μM Isoquercitrin is more effective as a neuroprotectant than the same concentration of EGCG.
In vivo In animal studies, both Isoquercitrin and quercetin administration resulted in reduced eosinophil counts in the bronchoalveolar lavage fluid (BALF), blood, and lung parenchyma. Isoquercitrin-treated mice uniquely exhibited decreased neutrophil counts in blood and lower IL-5 concentrations in lung homogenates. No significant changes were observed in mononuclear cell counts.
Source
Synonyms Isoquercetin, Isoquercitroside
Molecular Weight 464.38
Formula C21H20O12
CAS No. 21637-25-2

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (269.18 mM), Sonication is recommended.

TargetMolReferences and Literature

1. Jung SH, et al. Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells). Neurochem Int. 2010 Dec;57(7):713-21. 2. Rogerio AP, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007 Oct;56(10):402-8. 3. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet[J]. Planta medica. 2019. 4. Shim K S, Hwang Y H, Jang S A, et al. Ethanol Extract of Amomum tsao-ko Ameliorates Ovariectomy-Induced Trabecular Loss and Fat Accumulation[J]. Molecules. 2021, 26(4): 784.

TargetMolCitations

1. Jang S A, Hwang Y H, Yang H, et al. Water Extract of Mentha arvensis L. Attenuates Estrogen Deficiency-Induced Bone Loss by Inhibiting Osteoclast Differentiation. Frontiers in Pharmacology. 2021, 12. 2. Shim K S, Hwang Y H, Jang S A, et al. Ethanol Extract of Amomum tsao-ko Ameliorates Ovariectomy-Induced Trabecular Loss and Fat Accumulation. Molecules. 2021 Feb 3;26(4):784. doi: 10.3390/molecules26040784. 3. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet. Planta Medica. 2019, 85(14/15): 1128-1135

Related compound libraries

This product is contained In the following compound libraries:
Polyphenolic Natural Product Library Flavonoid Natural Product Library

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Keywords

Isotrifoliin 21637-25-2 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species Isoquercetin inhibit ISOQUERCITRIN Inhibitor Isoquercitroside inhibitor

 

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