Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 80.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 228.00 | |
50 mg | In stock | $ 378.00 | |
100 mg | In stock | $ 568.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 89.00 |
Description | SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer. |
In vitro | SX-682 significantly inhibited trafficking of PMN-MDSCs without altering CXCR2 ligand expression.?Trafficking of CXCR1+ macrophages was unaltered, possibly due to coexpression of CSF1R.?Reduced PMN-MDSC tumor infiltration correlated with enhanced accumulation of endogenous or adoptively transferred T cells.?Accordingly, tumor growth inhibition or the rate of established tumor rejection following programed death-axis (PD-axis) immune checkpoint blockade or adoptive cell transfer of engineered T cells was enhanced in combination with SX-682. |
Molecular Weight | 467.2 |
Formula | C19H14BF4N3O4S |
CAS No. | 1648843-04-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (535.10 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SX-682 1648843-04-2 Autophagy GPCR/G Protein Immunology/Inflammation CXCR cells allosteric recruitment suppressor Inhibitor tumor CXC chemokine receptors immunity MDSCs inhibit myeloid-derived SX682 SX 682 antitumor inhibitor