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Nanaomycin A

Catalog No. T16269 CAS 52934-83-5

Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).

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Nanaomycin A, CAS 52934-83-5

Pack Size	Availability	Price/USD
1 mg	35 days	$ 370.00
5 mg	35 days	$ 1,380.00
10 mg	35 days	$ 2,400.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).
Targets&IC50	DNMT3B:500 nM
In vitro	Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM[1]. Nanaomycin A (10, 100, 1000, 10000 nM) had a distinct cytotoxic effect in HCT116 (colon), A549 (lung), and HL60 (bone marrow) human tumor cell lines. Nanaomycin A (5 μM) had an 18-fold relative induction. Nanaomycin A (0.5, 5 μM) revealed induction of RASSF1A protein expression in A549 cells[2].

Molecular Weight	302.28
Formula	C16H14O6
CAS No.	52934-83-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (314.28 mM), Sonication is recommended.

References and Literature

1. Kuck D, et al.Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells.Mol Cancer Ther. 2010 Nov;9(11):3015-23. 2. Tanaka Y, et al.Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol.J Antibiot (Tokyo). 1999 Oct;52(10):880-8.

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Keywords

Nanaomycin A 52934-83-5 Chromatin/Epigenetic Metabolism Microbiology/Virology Parasite DNA Methyltransferase Dehydrogenase DNA MTases silenced antibiotics Inhibitor inhibit falciparum tumor Plasmodium suppressor DNMT3B genes malaria DNMTs inhibitor

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