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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5256 | All-trans-retinal | All trans-Retinal,Retinaldehyde,Vitamin A aldehyde | Others , Endogenous Metabolite |
All-trans-retinal (Vitamin A aldehyde) is a one of the major vitamin A metabolites in the retina. All-trans-RAL is regenerated to the visual chromophore, 11-cis-retinal in physiological conditions. | |||
T38219 | 11-cis Retinal | ||
11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. When 11-cis retinal absorbs a photon of light, it isomerizes to for... | |||
T19169 | 9-cis-Retinal | Others | |
9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to CRBP-I and CRBP-II (Kds: 8 nM and 5 nM). It expedites differentiation and ma... | |||
T39280 | Nitrofen | Others | |
Nitrofen is a selective contact herbicide. Nitrofen is a protoporphyrinogen oxidase and retinal dehydrogenase inhibitor. | |||
T12095 | Monomethyl fumarate | GPR , Drug Metabolite | |
Monomethyl fumarate is a potent agonist of GPR109A . | |||
T2055 | WS3 | EGFR , IκB/IKK | |
WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. | |||
T2026 | CYM5442 | S1P Receptor , LPL Receptor | |
CYM5442 is an S1P agonist, targeting to Sphingosine. | |||
T21807 | INCA-6 | Triptycene-1,4-quinone | Others |
INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 inhibits of CN-NFAT signaling by targeting of NFAT(P) substrate to the calcineurin (CN) phosphatase site. | |||
T5194 | SPHINX31 | Serine/threonin kinase | |
SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50: 5.9 nM). | |||
T29395 | 3-Diazirinophenylretinal | ||
3-Diazirinophenylretinal is a bioactive chemical. | |||
T34299 | Retinaloxime | trans-Retinaloxime | |
Retinaloxime is a retinoid. | |||
T25829 | Mopidamol | RA233,RA 233,RA-233,Rapenton,OLX 102 | PDE |
Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimental diabetes. | |||
T62858 | HGPR91 antagonist 3 | GPR | |
hGPR91 antagonist 3 is an orally active, potent, and selective hGPR91 antagonist. hGPR91 antagonist 3 is used to study hypertension, autoimmune diseases, and retinal angiogenesis. hGPR91 antagonist 3 has been shown to be... | |||
T5913 | Sulbutiamine | Bisibuthiamine | Antioxidant |
Sulbutiamine (Bisibuthiamine) is an antioxidant that act by inhibiting oxidative stress induced retinal ganglion cell death. | |||
T30480 | BiP inducer X | BIX | Apoptosis |
BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines. | |||
T0685 | Retinyl acetate | Vitamin A acetate,Retinyl (Retinol) Acetate,Retinol acetate | |
Retinyl acetate (Vitamin A acetate) is a group of unsaturated nutritional hydrocarbons, that contains retinal, retinol, retinoic acid, and several provitamins A carotenoids, among which beta-carotene is the most importan... | |||
T22282 | Brr2-IN-3 | Brr2 Inhibitor 9,Brr2 Inhibitor C9 | Others |
Brr2-IN-3 (Brr2 Inhibitor C9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa (a group of progressive retinal degenerative disorders). | |||
T72662 | NMDAR/TRPM4-IN-2 | ERK , TRP/TRPV Channel , NMDAR , iGluR | |
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss in mice.NMDAR/TRPM4-IN-2 has neuroprot... | |||
T37081 | HIOC | ||
Selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant. | |||
T13524 | 9-cis-β-Carotene | Others | |
9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. It inhibits photoreceptor degeneration and restores retinal function in vivo. |