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WS3

Catalog No. T2055 CAS 1421227-52-2

WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

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WS3, CAS 1421227-52-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 44.00
10 mg	In stock	$ 70.00
25 mg	In stock	$ 126.00
50 mg	In stock	$ 225.00
100 mg	In stock	$ 415.00
1 mL * 10 mM (in DMSO)	In stock	$ 64.00

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Purity: 98.81%

Purity: 98.77%

Purity: 98.54%

Purity: 97.93%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
Targets&IC50	Proliferation (β cells):28 nM(ec50)
In vivo	In the mouse β-cell line R7T1, WS3 induces cell proliferation with an EC50 of 0.074 μM. Additionally, WS3 reversibly induces cell proliferation in primary embryonic and adult retinal pigment epithelial cells.
Cell Research	R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells. (Only for Reference)

Molecular Weight	569.58
Formula	C28H30F3N7O3
CAS No.	1421227-52-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (163.3 mM)

Ethanol: 74 mg/mL (129.9 mM)

References and Literature

1. Shen W, et al. J Am Chem Soc. 2013, 135(5), 1669-1672. 2. Swoboda JG, et al. ACS Chem Biol. 2013, 8(7), 1407-1411.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Apoptosis Compound Library Anti-Lung Cancer Compound Library Anti-Cancer Compound Library Anti-Colorectal Cancer Compound Library Bioactive Compounds Library Max Anti-Ovarian Cancer Compound Library JAK-STAT Compound Library NO PAINS Compound Library

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Keywords

WS3 1421227-52-2 Angiogenesis JAK/STAT signaling NF-Κb Tyrosine Kinase/Adaptors EGFR IκB/IKK insulin pancreatic pigment proliferation epithelial β cell Inhibitor R7T1 diabete RPE inhibit WS 3 retinal WS-3 inhibitor

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