Powder: -20°C for 3 years | In solvent: -80°C for 1 year
9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to CRBP-I and CRBP-II (Kds: 8 nM and 5 nM). It expedites differentiation and maturation of rod photoreceptors in retinal organoids.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 123.00 | |
5 mg | 35 days | $ 494.00 | |
10 mg | 35 days | $ 658.00 |
Description | 9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to CRBP-I and CRBP-II (Kds: 8 nM and 5 nM). It expedites differentiation and maturation of rod photoreceptors in retinal organoids. |
In vitro | The incorporation of 9-cis-Retinal, as opposed to the commonly utilized all-trans retinoic acid, enhances the differentiation of rod photoreceptors in organoid cultures. This results in increased rhodopsin expression and the development of more mature mitochondrial morphology. Additionally, 9-cis-Retinal has the capability to associate with opsin, thereby forming functional rhodopsin [3]. |
In vivo | Treatment with 9-cis-retinal significantly restored cone response in interphotoreceptor retinoid-binding protein (IRBP)-/- mice, demonstrating that retinoid deficiency is responsible for cone dysfunction [4]. |
Molecular Weight | 284.44 |
Formula | C20H28O |
CAS No. | 514-85-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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9-cis-Retinal 514-85-2 Others 9cisRetinal 9 cis Retinal inhibitor inhibit