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Monomethyl fumarate

Catalog No. T12095   CAS 2756-87-8

Monomethyl fumarate is a potent agonist of GPR109A .

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Monomethyl fumarate Chemical Structure
Monomethyl fumarate, CAS 2756-87-8
Pack Size Availability Price/USD Quantity
500 mg In stock $ 42.00
1 mL * 10 mM (in DMSO) In stock $ 46.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Monomethyl fumarate is a potent agonist of GPR109A .
In vitro Monomethyl fumarate (25 μM; 24?hours) attenuates 7β-OHC-induced cytotoxicity: cell growth inhibition; decreased cell viability; mitochondrial dysfunction; and cell death induction[3].
Molecular Weight 130.1
Formula C5H6O4
CAS No. 2756-87-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (691.78 mM), sonification is recommended.

H2O: 8 mg/mL (61.49 mM), ultrasonic and warming and heat to 60°C

TargetMolReferences and Literature

1. Tang H, et al. The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist. Biochem Biophys Res Commun. 2008 Oct 31;375(4):562-5. 2. Jiang D, et al. Monomethyl Fumarate Protects the Retina From Light-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2019 Mar 1;60(4):1275-1285. 3. Sghaier R, et al. Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrialalterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol. J Steroid Biochem Mol Biol. 2019 Nov;194:105432.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Traditional Chinese Medicine Monomer Library FDA-Approved & Pharmacopeia Drug Library Approved Drug Library Chinese Pharmacopoeia Natural Product Library Endocrinology-Hormone Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library

Related Products

Related compounds with same targets
TC-O 9311 free base GLPG1205 AMG 837 calcium hydrate Latanoprost acid PSN 375963 hGPR91 antagonist 3 GLPG0974 GSK256073

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Keywords

Monomethyl fumarate 2756-87-8 Endocrinology/Hormones GPCR/G Protein Metabolism Drug Metabolite GPR Dimethyl metabolite neuroprotective DMF HCA2 HM74A retinal inhibit PUMA-G fumarate GPR109A Monomethyl Inhibitor Monomethyl Fumarate HCAR2 inhibitor

 

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