pro-tumor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T76371	Tumor targeted pro-apoptotic peptide
	The compound, tumor-targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2), functions as an anti-tumor agent by disrupting mitochondrial membranes to induce apoptosis, demonstrating anticancer efficacy in mice [1].
T22414	RBN012759		PARP
	RBN012759, a potent and selective PARP14 inhibitor, decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants.		PARP
T8193	α-Thujone	Thujone,ALPHA-(-)-THUJONE	Apoptosis , Reactive Oxygen Species , GABA Receptor , AChR , Parasite , Autophagy
	α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
T4169	N-Nitroso-N-methylurea	1-Methyl-1-nitrosourea,N-Methyl-N-nitrosourea,Methylnitrosourea	Others , DNA Alkylator/Crosslinker
	N-Nitroso-N-methylurea (Methylnitrosourea) is a nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.		Others , DNA Alkylator/Crosslinker
TN1291	7,3',4'-Tri-O-methylluteolin	5-Hydroxy-3',4',7-trimethoxyflavone	TNF , COX , Interleukin
	7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC value of 19.0 ug/ml		TNF , COX , Interleukin
T77059	Leronlimab	PRO 140	CCR
	Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. leronlimumab has both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronl...		CCR
T14075	A-802715		IL Receptor
	A-802715 is a novel methylxanthine derivative that decreases the endogenous formation and blood levels of pro-inflammatory substances and increases the formation and blood levels of anti-inflammatory substances such as i...		IL Receptor
T3395	Timosaponin AIII	Filiferin B,AneMarsaponin A3,Timosaponin A3	AChE , mTOR
	Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC...		AChE , mTOR
T31020	CP 461	OSI 461,UNII-68OJX9I7DT,CP-461,CP461	Apoptosis , PDE
	CP 461 (UNII-68OJX9I7DT), a specific PDE2A inhibitor, is a novel pro-apoptotic compound that inhibits cyclic GMP phosphodiesterase but not cyclooxygenase-1 or -2. CP 461 inhibits the growth of a variety of human tumor ce...		Apoptosis , PDE
T77493	Murlentamab	3C23K,GM102	Others
	Murlentamab (GM102) is a humanized anti-AMhRII antibody. Murlentama has potential antitumor activity that induces macrophage-mediated antitumor-dependent cell-mediated cytotoxic effects (ADCC). Murl can stimulate the pro...		Others
T67924	ABzOH
	ABzOH is a benzoic acid derivative, similar in structure to non-steroidal anti-inflammatory drugs such as aspirin, with anti-inflammatory, anti-tumor and anti-proliferative effects. ABzOH can not only inhibit the express...
T15594	MKC8866		IRE1
	MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate ca...		IRE1
T3S0737	Flavokawain A	Flavokavain A	Apoptosis , p38 MAPK
	NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significant...		Apoptosis , p38 MAPK
T36715	Tetrac	Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid	Apoptosis , EGFR
	Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.Tetrac...		Apoptosis , EGFR
T1185	Rofecoxib	MK 966,MK-0966	COX
	Rofecoxib (MK 966) binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecoxib is a synthetic, nonsteroidal derivative of pheny...		COX
T60202	MMRi62	7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol	Ferroptosis
	MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity aga...		Ferroptosis
T2S2264	Linalool	Linalol,(±)-Linalool,Phantol	Apoptosis , IL Receptor , TNF , Endogenous Metabolite , iGluR
	1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was protected against LPS/GalN-induced liver injury th...
T38406	L-Proline 4-methoxy-β-naphthylamide hydrochloride	H-Pro-4MβNA hydrochloride,L-Proline 4-methoxy-β-naphthylamide hydrochloride
	L-Proline 4-methoxy-β-naphthylamide hydrochloride, also known as H-Pro-4MβNA hydrochloride, is a chemical compound utilized in the preparation of Fap-activated anti-tumor compounds.
TMA2576	Episappanol		IL Receptor , TNF
	Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α).		IL Receptor , TNF
T80687	γ3-MSH
	γ3-MSH, originating from the N-terminal segment of pro-opiomelanocortin (POMC), induces aldosterone secretion in cultured human adrenal tumor cells [1].