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Timosaponin AIII

Catalog No. T3395   CAS 41059-79-4
Synonyms: Filiferin B, AneMarsaponin A3, Timosaponin A3

Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 μM, BT474 cells; 6 μM, MDAMB231). The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.

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Timosaponin AIII Chemical Structure
Timosaponin AIII, CAS 41059-79-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 30.00
5 mg In stock $ 64.00
10 mg In stock $ 113.00
25 mg In stock $ 239.00
50 mg In stock $ 343.00
100 mg In stock $ 515.00
1 mL * 10 mM (in DMSO) In stock $ 97.00
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Purity: 99.61%
Purity: 99.14%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 μM, BT474 cells; 6 μM, MDAMB231). The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.
Targets&IC50 mTORC1(MDAMB231):6 μM, mTORC1(BT474 cells):2.5 μM
Source
Synonyms Filiferin B, AneMarsaponin A3, Timosaponin A3
Molecular Weight 740.92
Formula C39H64O13
CAS No. 41059-79-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 135 mM

TargetMolReferences and Literature

1. Wu ZT, et al. Acta Pharmacol Sin. 2014 Sep;35(9):1188-98.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Selected Plant-Sourced Compound Library Apoptosis Compound Library HIF-1 Signaling Pathway Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Anti-Diabetic Compound Library Cancer Cell Differentiation Compound Library Stem Cell Differentiation Compound Library Neural Regeneration Compound Library Anti-Aging Compound Library

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Keywords

Timosaponin AIII 41059-79-4 Neuroscience PI3K/Akt/mTOR signaling AChE mTOR Filiferin B Cholinesterase (ChE) inhibit Inhibitor AneMarsaponin A3 Timosaponin A3 inhibitor

 

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