Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 μM, BT474 cells; 6 μM, MDAMB231). The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 113.00 | |
25 mg | In stock | $ 239.00 | |
50 mg | In stock | $ 343.00 | |
100 mg | In stock | $ 515.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 μM, BT474 cells; 6 μM, MDAMB231). The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both. |
Targets&IC50 | mTORC1(MDAMB231):6 μM, mTORC1(BT474 cells):2.5 μM |
Source |
Synonyms | Filiferin B, AneMarsaponin A3, Timosaponin A3 |
Molecular Weight | 740.92 |
Formula | C39H64O13 |
CAS No. | 41059-79-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 135 mM
You can also refer to dose conversion for different animals. More
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Timosaponin AIII 41059-79-4 Neuroscience PI3K/Akt/mTOR signaling AChE mTOR Filiferin B Cholinesterase (ChE) inhibit Inhibitor AneMarsaponin A3 Timosaponin A3 inhibitor