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MKC8866

Catalog No. T15594 CAS 1338934-59-0

MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate cancer (PCa) tumor growth.

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MKC8866, CAS 1338934-59-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 80.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 320.00
25 mg	In stock	$ 538.00
50 mg	In stock	$ 779.00
100 mg	In stock	$ 1,090.00
500 mg	In stock	$ 2,180.00
1 mL * 10 mM (in DMSO)	In stock	$ 213.00

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Purity: 99.35%

Purity: 99.28%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate cancer (PCa) tumor growth.
Targets&IC50	IRE1 Rnase:0.29 μM
In vitro	MKC8866 strongly suppresses DTT-induced X-box-binding protein 1-spliced (XBP1s) expression (EC50: 0.52?μM) and unstressed RPMI 8226 cells (IC50: 0.14?μM). MKC8866 (0.2-10 μM; 3 days) inhibits the viability of all four cell lines in a dose-dependent manner under normal conditions, with the most robust effect in LNCaP cells, and MKC8866 (20 μM; 72?hours) is sufficient to completely block NSC 125973-induced expression of XBP1s [1]. MKC8866 (20?μM; 6 days) reduces the proliferation of all breast cancer cell lines and MKC8866 (20 μM; 48 hours) decreases the number of cells entering the S phase [2].
In vivo	MKC8866 (oral ; 300 mg/kg; for 28 days) decreases tumor regrowth post-NSC 125973 withdrawal [1].

Molecular Weight	361.35
Formula	C18H19NO7
CAS No.	1338934-59-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 16.67 mg/mL (46.13 mM), Sonication is recommended.

References and Literature

1. Sheng X, et al. IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling. Nat Commun. 2019 Jan 24;10(1):323. 2. Logue SE, et al. Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. Nat Commun. 2018 Aug 15;9(1):3267.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Hematonosis Compound Library Anti-Prostate Cancer Compound Library Bioactive Compounds Library Max Covalent Inhibitor Library Kinase Inhibitor Library Anti-Aging Compound Library Anti-Cancer Compound Library Anti-Breast Cancer Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MKC8866 1338934-59-0 Cell Cycle/Checkpoint IRE1 Inositol requiring enzyme 1 inhibit Inhibitor MKC-8866 MKC 8866 inhibitor

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