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RBN012759

Catalog No. T22414 CAS 2360851-29-0

RBN012759, a potent and selective PARP14 inhibitor, decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants.

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RBN012759, CAS 2360851-29-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 133.00
5 mg	In stock	$ 328.00
10 mg	In stock	$ 555.00
25 mg	In stock	$ 827.00
50 mg	In stock	$ 1,140.00
100 mg	In stock	$ 1,540.00
200 mg	In stock	$ 1,990.00
1 mL * 10 mM (in DMSO)	In stock	$ 365.00

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Purity: 99.96%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	RBN012759, a potent and selective PARP14 inhibitor, decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants.
Targets&IC50	PARP5b:10 μM (IC50), PARP11:1 μM (IC50), PARP6:4 μM (IC50), PARP14:<3 nM (IC50), PARP12:5 μM (IC50), PARP16:6 μM (IC50), PARP15:3 μM (IC50), PARP5a:8 μM (IC50), PARP10:1 μM (IC50), PARP7:4 μM (IC50), PARP4:10 μM (IC50), PARP8:20 μM (IC50)

Molecular Weight	378.46
Formula	C19H23FN2O3S
CAS No.	2360851-29-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 12 mg/mL (31.71 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Schenkel L, et, al. A potent and selective PARP14 inhibitor decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants. AACR Annual Meeting 2020.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Prostate Cancer Compound Library Orally Active Compound Library Anti-Cardiovascular Disease Compound Library DNA Damage & Repair Compound Library Inhibitor Library Preclinical Compound Library Anti-Aging Compound Library Anti-Cancer Compound Library Anti-Ovarian Cancer Compound Library Immunology/Inflammation Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RBN012759 2360851-29-0 Chromatin/Epigenetic DNA Damage/DNA Repair PARP poly ADP ribose polymerase pro-tumor cancer PARP14 macrophage RBN 012759 Inhibitor inflammatory inhibit RBN-012759 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.