Shopping Cart
- Remove All
Your shopping cart is currently empty
RBN012759
🥰Excellent
Catalog No. T22414Cas No. 2360851-29-0
RBN012759 inhibits PARP14 protein with an IC50 value of 0.003 μM and is more than 300-fold selective over all PARP family members.[2]
RBN012759
🥰Excellent
Purity: 99.96%
Catalog No. T22414Cas No. 2360851-29-0
RBN012759 inhibits PARP14 protein with an IC50 value of 0.003 μM and is more than 300-fold selective over all PARP family members.[2]
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $107 | In Stock | |
| 5 mg | $263 | In Stock | |
| 10 mg | $455 | In Stock | |
| 25 mg | $679 | In Stock | |
| 50 mg | $987 | In Stock | |
| 100 mg | $1,380 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $365 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "RBN012759"
Olaparib
Cited
KU0059436, AZD2281
T3015763113-22-0
Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 μM), and is selective and orally active. Olaparib exhibits autophagy and mitochondrial autophagy activation activity.
- $31
Size
QTY
CitedOUL35
NSC39047
T90246336-34-1
OUL35 (NSC-39047) is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.
- $31
Size
QTY
XAV-939 Cited
XAV939, NVP-XAV939
T1878284028-89-3
XAV-939 (NVP-XAV939) is a Tankyrase (TNKS) inhibitor that inhibits TNKS1 and TNKS2 (IC50=11/4 nM). XAV-939 selectively inhibits Wnt/β-catenin-mediated transcription.
- $48
Size
QTY
CitedNiraparib Cited
MK-4827
T32311038915-60-4
Niraparib (MK-4827) is a PARP inhibitor that selectively targets PARP1 and PARP2 (IC50=3.8/2.1 nM), exhibiting antitumor activity, inhibiting DNA damage repair, and inducing apoptosis.
- $55
Size
QTY
Cited4'-Methoxychalcone
T7443959-23-9
4'-Methoxychalcone with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities.
- $43
Size
QTY
3-Methoxybenzamide
3-MBA
T74395813-86-5
3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase.
- $30
Size
QTY
3-Aminobenzamide
PARP-IN-1, INO-1001, INO1001, INO 1001, 3-ABA, 3-AB
T63293544-24-9
3-Aminobenzamide (PARP-IN-1) is a potent PARP inhibitor (IC50 < 50 nM in CHO cells) and mediates oxidant-induced myocyte dysfunction during reperfusion.
- $37
Size
QTY
VPC-70063
Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-
T6001913571-44-3
VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C downstream pathway inhibition of 94%. VPC-70063 can be used for studies about anticancer.
- $47
Size
QTY
Picolinamide
Picolinoylamide, 2-Pyridinecarboxamide, 2-Picolinamide, 2-Carbamoylpyridine
T69421452-77-3
Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
- $29
Size
QTY
Benzamide
Phenylcarboxyamide, Benzoylamide, Amid kyseliny benzoove
T678055-21-0
Benzamide (Amid kyseliny benzoove), an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.
- $30
Size
QTY
NU1025
NSC 696807
T691290417-38-2
NU1025 (NSC-696807) is a potent PARP inhibitor with IC50 of 400 nM.
- $40
Size
QTY
Niraparib tosylate monohyrate
T94971613220-15-7
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway.
- $55
Size
QTY
Select Batch
Purity:99.96%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | RBN012759 inhibits PARP14 protein with an IC50 value of 0.003 μM and is more than 300-fold selective over all PARP family members.[2] |
| Targets&IC50 | PARP8:20 μM (IC50), PARP4:10 μM (IC50), PARP7:4 μM (IC50), PARP10:1 μM (IC50), PARP5a:8 μM (IC50), PARP15:3 μM (IC50), PARP16:6 μM (IC50), PARP12:5 μM (IC50), PARP14:<3 nM (IC50), PARP6:4 μM (IC50), PARP11:1 μM (IC50), PARP5b:10 μM (IC50) |
| In vitro | METHODS: B cells were treated with RBN012759 (1 or 0.33 μM ) and added once daily. Cultures were harvested and counted on day 5 and the supernatant was collected for ELISA. RESULTS RBN012759 induced a decrease in IgE. [1] METHODS: RBN0127599 (0.001-10 μM) was tested in IFN-γ stimulated human primary macrophages and RAW264.7 cells to observe the effect of RBN0127599 on the expression of PARP14 protein in vitro. RESULTS The EC50 value (half-maximal effect concentration) observed in RAW264.7 cells was 10 μM, and in human macrophages it was 8 μM, indicating that RBN0127599 showed effective inhibition of the target PARP14 within these concentration ranges. [2] |
| In vivo | METHODS: RBN012759 (500 mg/kg,i.g) twice daily. Investigators collected plasma samples 2 hours after the last dose (i.e., after the penultimate dose) and on the last day to determine plasma levels of RBN012759 using liquid chromatography-mass spectrometry. RESULTS RBN012759 was effective in reducing allergen-induced IgE (immunoglobulin E) overproduction and mucus overproduction. treatment with RBN012759 resulted in a decrease in overall mucus scores in lung tissue, while the number of inflammatory cells recovered from bronchoalveolar lavage fluid (BALF) and the proportion of eosinophils recovered were significantly reduced in the bronchial-alveolar lavage fluid (BALF) of RBN012759-treated mice. were significantly reduced. [1] METHODS: RBN012759 was tested in a C57BL/6 mouse model by oral administration (BID) at doses of 300 mg/kg and 500 mg/kg for 7 days. RESULTS The 500 mg/kg group showed an increase in PARP14 protein levels, while the 300 mg/kg group did not, indicating that RBN012759 can effectively and specifically target PARP14 in vivo at higher doses. [2] |
| Molecular Weight | 378.46 |
| Formula | C19H23FN2O3S |
| Cas No. | 2360851-29-0 |
| Smiles | O[C@H]1CC[C@@H](CC1)SCc1nc2cc(OCC3CC3)cc(F)c2c(=O)[nH]1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 12 mg/mL (31.71 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||
Sci Citations
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy RBN012759 | purchase RBN012759 | RBN012759 cost | order RBN012759 | RBN012759 chemical structure | RBN012759 in vivo | RBN012759 in vitro | RBN012759 formula | RBN012759 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.