Search Result

Search Results for " p25 "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T2304	SP2509	HCI-2509	Apoptosis , Histone Demethylase
	SP2509 is a specific histone demethylase LSD1 inhibitor(IC50 =13 nM).		Apoptosis , Histone Demethylase
T2035	WHI-P258		EGFR , JAK , JNK
	WHI-P258 is a dimethoxyquinazoline inhibitor of JAK3. This compound binds JAK3 weakly and may be used as a JAK-binding negative control in the development of new therapeutics.		EGFR , JAK , JNK
T7685	USP25/28 inhibitor AZ1	AZ1	DUB
	USP25/28 inhibitor AZ1 (AZ1) (AZ1) is an inhibitor of ubiquitin specific protease (USP) 25/28		DUB
T14984	CLP257		Potassium Channel
	CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it al...		Potassium Channel
T14334	ASP2535		GlyT
	ASP2535 is a potent, selective, orally bioavailable, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor.ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's...		GlyT
T69855	USP25/28-IN-AZ2
	USP25/28-IN-AZ2 is a novel potent, selective, dual usp25/28 inhibitor
T61439	DSS30		Beta Amyloid , BACE , CDK
	DSS30 is a P25/CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of β-amyloid (Aβ).DSS30 can be used for the prevention and tr...		Beta Amyloid , BACE , CDK
T6358	1-Azakenpaullone	azakenpaullone	GSK-3
	1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.		GSK-3
T21715	BRD6688		HDAC
	BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes		HDAC
T6787	BIO-acetoxime	BIA,GSK-3 Inhibitor X	Apoptosis , GSK-3 , HSV
	BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.		Apoptosis , GSK-3 , HSV
T37207L	Cdk5 Substrate acetate		CDK
	Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 Substrate aceta...		CDK
T5200	Indirubin-3'-monoxime	Indirubin-3'-oxime	GSK-3 , Lipoxygenase , CDK
	Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).		GSK-3 , Lipoxygenase , CDK
T14943	CGP60474		VEGFR , CDK , PKC
	CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently.		VEGFR , CDK , PKC
T2247	KenPaullone	9-Bromopaullone,NSC-664704	GSK-3 , CDK
	KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp...		GSK-3 , CDK
T10172	5-Iodo-indirubin-3'-monoxime		GSK-3 , CDK
	5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s: 9, 20 and 25 nM).		GSK-3 , CDK
T24734	RP-106	RP 106
	RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.
T25650	LDN-193665	LDN 193665,LDN193665
	LDN-193665 is a potent inhibitor of tau kinase. It acts by targeting CDK5/p25 and GSK3β.
T63184	CDK5-IN-2
	CDK5-IN-2 (compound 15) is a highly selective CDK5 inhibitor that acts on CDK5/p25 (IC50: 0.2 nM) and CDK2/CycA (IC50: 23 nM).
T61890	(E/Z)-BIO-acetoxime
	(E/Z) - BIO-acetoxime is effective and selective GSK-3 α/β Inhibitors. For GSK-3 α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B, IC50 are 10nM, 2.4 μM, 4.3 μ M, 63 μ M, respectively。
T21377	Aloisine A
	Aloisine A is a potent and selective CDK/GSK-3 inhibitor. IC50 data of Aloisine A: Cdk1/cyclin B (IC50: 150nM), Cdk2/cyclin A (IC50: 120nM), Cdk2/cyclin E (IC50: 400nM), Cdk5/p25 (IC50: 200nM), Cdk5/p35 (IC50: 160nM), GS...
T37207	Cdk5 Substrate	Cdk5 Substrate
	Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 substrate is a ...
T61362	CDK5-IN-3
	CDK5-IN-3 (compound 11) is a highly potent and selective inhibitor of CDK5, demonstrating significant inhibition with IC50 values of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. This compound holds promise ...
T63851	CDK9/10/GSK3β-IN-1
	CDK9/10/GSK3β-IN-1 is a kinase inhibitor (Flavopiridol analogue) that effectively inhibits HsGSK3β, HsCDK9/CyclinT, HsCDK5/p25 and HsCDK2/CyclinA with IC50 values of 59 nM, 64 nM, 1.093 μM and 1.725 μM, respectively. CDK...
T21966	MeBIO		GSK-3 , Aryl Hydrocarbon Receptor , CDK
	MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.		GSK-3 , Aryl Hydrocarbon Receptor , CDK
T2113	PHA-793887	PHA 793887,PHA793887	Apoptosis , CDK
	PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors.		Apoptosis , CDK
T12617L	(R)-CR8	(R)-CR8,(R)-Isomer,CR8	Apoptosis , CDK
	(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.		Apoptosis , CDK
T12617	(R)-CR8 trihydrochloride	CR8, (R)-Isomer trihydrochloride	Apoptosis , CDK
	(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis.		Apoptosis , CDK
T5533	MC180295	(rel)-MC180295	CDK
	MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.		CDK
T16359	NU6140		CDK , Aurora Kinase
	NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also e...		CDK , Aurora Kinase
T8484	JSH-150		CDK
	JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).		CDK
T11345L	Lerociclib dihydrochloride	G1T38 dihydrochloride	CDK
	Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively.		CDK
TQ0068	NVP-LCQ195	AT9311,LCQ-195	CDK
	NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).		CDK
T23093	NSC 693868		Others
	CDKs and GSK-3 inhibitor		Others
T11345	Lerociclib	G1T38	CDK
	Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 2nM, 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively.		CDK

Compounds

SP2509

T2304

Synonym: HCI-2509

Target: Apoptosis, Histone Demethylase

WHI-P258

T2035

Synonym:

Target: EGFR, JAK, JNK

USP25/28 inhibitor AZ1

Target: Potassium Channel

Target: Beta Amyloid, BACE, CDK

1-Azakenpaullone

T6358

Synonym: azakenpaullone

Synonym: BIA,GSK-3 Inhibitor X

Target: Apoptosis, GSK-3, HSV

Cdk5 Substrate acetate

T37207L

Synonym:

Target: CDK

Indirubin-3'-monoxime

T5200

Synonym: Indirubin-3'-oxime

Target: GSK-3, Lipoxygenase, CDK

CGP60474

T14943

Synonym:

Target: VEGFR, CDK, PKC

KenPaullone

T2247

Synonym: 9-Bromopaullone,NSC-664704

Target: GSK-3, CDK

5-Iodo-indirubin-3'-monoxime

Synonym: LDN 193665,LDN193665

Synonym: Cdk5 Substrate

Target: GSK-3, Aryl Hydrocarbon Receptor, CDK

PHA-793887

T2113

Synonym: PHA 793887,PHA793887

Target: Apoptosis, CDK

(R)-CR8

T12617L

Synonym: (R)-CR8,(R)-Isomer,CR8

Target: Apoptosis, CDK

(R)-CR8 trihydrochloride

T12617

Synonym: CR8, (R)-Isomer trihydrochloride

Target: Apoptosis, CDK

MC180295

T5533

Synonym: (rel)-MC180295

Target: CDK, Aurora Kinase

Lerociclib dihydrochloride

T11345L

Synonym: G1T38 dihydrochloride

Target: CDK

NVP-LCQ195

TQ0068

Synonym: AT9311,LCQ-195

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00873	Lipocalin-2/LCN2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Lipocalin-2/LCN2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.7 kDa and the accession number is P80188-1.
TMPK-01289	NGAL/Lipocalin-2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	NGAL/Lipocalin-2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 21.51 kDa and the accession number is XP_005580845.3.
TMPY-00531	TMED9 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	TMED9 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 45.8 kDa and the accession number is A0A024R7M0.
TMPK-00085	NGAL/Lipocalin-2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	NGAL/Lipocalin-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 47.2 kDa and the accession number is P80188-1.
TMPY-00148	TMED9 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TMED9 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.8 kDa and the accession number is A0A024R7M0.
TMPH-01088	CBX5 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphor...
TMPJ-00082	NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables it to be secreted and form complexes w...
TMPH-00603	Cytidylate kinase Protein, E. coli, Recombinant (His & SUMO)	E. coli	E. coli
	ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors.
TMPY-02259	FKBP25/FKBP3 Protein, Human, Recombinant (GST)	Human	E. coli
	FKBP3 is a member of FK506-binding proteins (FKBPs). miR-145-5p overexpression suppressed cell proliferation of NSCLC cells which was abrogated by FKBP3 overexpression, that FKBP3/Sp1/HDAC2/p27 control cell proliferation...
TMPJ-01068	FKBP25/FKBP3 Protein, Human, Recombinant (His)	Human	E. coli
	FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell prolif...
TMPH-02683	GSTP1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). ...
TMPH-01399	GSTP1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). ...
TMPH-01398	GSTP1 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). ...
TMPJ-00499	GSTP1 Protein, Human, Recombinant	Human	E. coli
	Glutathione S-transferase P (GSTP1) is an enzyme that contains 1 GST C-terminal domain, 1 GST N-terminal domain. GSTP1 belongs to the GST superfamily, the GSTs are a family of enzymes that play an important role in deto...