Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
2 mg | In stock | $ 40.00 | |
5 mg | In stock | $ 68.00 | |
10 mg | In stock | $ 98.00 | |
25 mg | In stock | $ 197.00 | |
50 mg | In stock | $ 349.00 | |
100 mg | In stock | $ 576.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 75.00 |
Description | CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently. |
Targets&IC50 | CDK9-CyclinT:13 nM, CDK5-p25:10 nM, CDK4-CyclinD:216 nM, CDK2-CyclinE:3 nM, CDK7-CyclinH:200 nM, CDK2-CyclinA:4 nM, CDK1-CyclinB:26 nM, VEGFR2:84 nM |
In vitro | The IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/CyclinB, CDK2/CyclinE, CDK2/CyclinA, CDK5/p25, CDK7/CyclinH, CDK4/CyclinD and CDK9/cycT, respectively[4]. |
In vivo | In the LPS endotoxemia model, CGP60474 (10?mg/kg; i.p.) inhibits the IL-6 level and increases the survival rate[3]. |
Molecular Weight | 355.82 |
Formula | C18H18ClN5O |
CAS No. | 164658-13-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (140.52 mM)
H2O: < 0.1 mg/mL (insoluble)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CGP60474 164658-13-3 Angiogenesis Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling Tyrosine Kinase/Adaptors VEGFR CDK PKC inhibit endotoxemic CGP-60474 Cyclin dependent kinase LPS Inhibitor Protein kinase C selective survival ATP-competitive IL-6 level CGP 60474 inhibitor