osteoblastic — TargetMol Chemicals

Cat No.	Product Name	Targets
TN1148	Isopsoralenoside	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Antibacterial
	Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.
T5751	Tigogenin	Others
	Tigogenin is one of steroidal sapogenins which is widely used for synthesizing steroid drugs. It might have protective effect on bone and be helpful in preventing the development of osteoporosis.	Others
TN1008	Psoralenoside	CaMK , Calcium Channel , Histamine Receptor
	Psoralenoside is a natural product isolated from the fruits of Psoralea corylifolia, shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.	CaMK , Calcium Channel , Histamine Receptor
T13589	Caesappanin C	Others
	Caesappanin C, extracted from the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro.	Others
T5S2129	Sciadopitysin	TNF , NF-κB
	Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effects on antimycin A-induced toxicity in o...	TNF , NF-κB
T7190	Actein	Apoptosis , Akt , JNK , Autophagy
	Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways in...	Apoptosis , Akt , JNK , Autophagy
TN3754	Dalbergiphenol	Others
	Dalbergiphenol shows antiosteoporotic activity, dalbergiphenol treatment can effectively prevent OVX-induced increase in bone loss and decrease in bone strength possibly by increasing osteoblastic activities and by decre...	Others
TN3753	Dalbergioidin	Tyrosinase , ROS , Akt , PI3K , TGF-beta/Smad
	Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator or...	Tyrosinase , ROS , Akt , PI3K , TGF-beta/Smad
TN2534	1-Hydroxy-2,3,5-trimethoxyxanthone	IκB/IKK , Calcium Channel , NOS , 5-HT Receptor , COX
	1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type vo...	IκB/IKK , Calcium Channel , NOS , 5-HT Receptor , COX
TN2533	1-Hydroxy-2,3,4,7-tetramethoxyxanthone	5-HT Receptor
	1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 value of 6.6±1.4 uM. 1-Hydroxy-2,3,4,7-...	5-HT Receptor
TN4094	Gallocatechin gallate	IL Receptor , NF-κB , ROS , MAPK , PPAR , Fatty Acid Synthase
	Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation through MAPK and NF-ÎºB signaling; it also may have anti-diabeti...