neurodegeneration — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10122	Anti-neurodegeneration agent 1		Others
	Anti-neurodegeneration agent 1 a neurodegeneration-targeting agent.		Others
T1880	P7C3		Others
	The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, be...		Others
T9491	Pyraclostrobin		Antibacterial , Antifungal
	Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.		Antibacterial , Antifungal
T4470	Pyridostatin TFA		DNA/RNA Synthesis
	Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.		DNA/RNA Synthesis
T5827	BI-6C9		Apoptosis , Others , Mitochondrial Metabolism
	BI-6C9 is an inhibitor of tBid (Kd = 20 µM).BI-6c9 prevented MOMP and mitochondrial fission, and protected the cells from cell death.		Apoptosis , Others , Mitochondrial Metabolism
T6403	Siponimod	BAF-312	S1P Receptor , LPL Receptor
	BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for S1P1 and S1P5 receptors exhibi...		S1P Receptor , LPL Receptor
T8408	GKT136901	AK120765	NADPH-oxidase , NADPH
	GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite		NADPH-oxidase , NADPH
T1899	Pyridostatin	RR82,Pyridostatin Trifluoroacetate Salt	DNA/RNA Synthesis
	Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres.		DNA/RNA Synthesis
T6S1369	Vitexin	Apigenin-8-C-glucoside	Antioxidant
	1. Vitexin has antinociceptive and antispasmodic activities. 2. Vitexin exhibits a prominent first-pass effect. 3. Vitexin has antioxidant, antimyeloperoxidase, and α-glucosidase inhibitory activities. 4. Vitexin can eit...		Antioxidant
T0682	Lamivudine	GR109714X,BCH-189	HIV Protease , Reverse Transcriptase
	Lamivudine (BCH-189) is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.		HIV Protease , Reverse Transcriptase
T6561	Laquinimod	LAQ,ABR-215062	Apoptosis , Others , NF-κB
	Laquinimod (LAQ) is an effective immunomodulator, which is currently under development in phase III trials for the treatment of multiple sclerosis as an oral therapy.		Apoptosis , Others , NF-κB
T15199	Edicotinib	JNJ-527,JNJ-40346527	c-Fms , FLT , CSF-1R , c-Kit
	Edicotinib (JNJ-527) is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT and FLT3 (IC50: 20 nM and 190 nM). It has the pote...		c-Fms , FLT , CSF-1R , c-Kit
T10499	H3 receptor-MO-1		Histamine Receptor
	H3 receptor-MO-1 is a potent modulator of the histamine H3 receptor (H3 receptor) and can be used to study neurodegeneration and cognitive disorders.		Histamine Receptor
T73599	TSPO ligand-1		Autophagy
	TSPO ligand-1 has affinity for peripheral and central benzodiazepine receptors.TSPO ligand-1 is an AUTAC4-binding protein in the transmembrane domain of the outer mitochondrial membrane, which induces mitochondrial autop...		Autophagy
T12295	Oleoylcarnitine	Oleoyl-L-carnitine	Endogenous Metabolite
	Oleoylcarnitine (Oleoyl-L-carnitine) inhibits adenine nucleotide translocase (AdNT) activity with an ic50 of 14 μM.Oleoylcarnitine is an important indicator of neurodegeneration.		Endogenous Metabolite
T5618	AK-1		Sirtuin
	AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.		Sirtuin
T27710	K6PC-5	K6PC5,K6PC 5	S1P Receptor
	K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated ...		S1P Receptor
T37621	Ezeprogind disulfate		Beta Amyloid
	Ezeprogind disulfate is a neurotrophic inducer. Ezeprogind disulfate targets all causes of neurodegeneration including Abeta protein or tau protein. Ezeprogind disulfate can be used for the research of neurological disor...		Beta Amyloid
T12269	NUCC-390		CXCR
	NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100. This compound facilitates nerve functional recovery following neurodeg...		CXCR
T5S1467	Cucurbitacin E		CDK , Autophagy
	Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has pot...		CDK , Autophagy