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Cucurbitacin E

Catalog No. T5S1467   CAS 18444-66-1

Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has potent anti-proliferative, antineoplastic, anti-inflammatory and analgesic actions.

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Cucurbitacin E Chemical Structure
Cucurbitacin E, CAS 18444-66-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 54.00
5 mg In stock $ 117.00
10 mg In stock $ 187.00
25 mg In stock $ 316.00
50 mg In stock $ 469.00
100 mg In stock $ 677.00
1 mL * 10 mM (in DMSO) In stock $ 143.00
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Purity: 98.88%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has potent anti-proliferative, antineoplastic, anti-inflammatory and analgesic actions.
In vitro the anti-proliferation and cell cycle G2/M arrest induced by Cucurbitacin E (CuE)?in CRC cells.?MPM-2 flow cytometry tests show that CuE-treated cells accumulated in metaphase (CuE 2.5-7.5 μM).?CuE produced G2/M arrest as well as the downregulation of CDC2 and cyclin B1 expression and dissociation.?Both effects increased proportionally with the dose of CuE;?however, the inhibition of proliferation, arrest of mitosis, production of reactive oxygen species (ROS), and loss of mitochondrial membrane potential (ΔΨm) were found to be dependent on the quantity of CuE used to treat the cancer cells.?In addition, cell cycle arrest in treated cells coincided with the activation of the gene GADD45(α, β, γ).?Incubation with CuE resulted in the binding of GADD45γ to CDC2, which suggests that the delay in CuE-induced mitosis is regulated by the overexpression of GADD45γ.?CuE may have antitumor activities in established CRC[3].
Source
Molecular Weight 556.69
Formula C32H44O8
CAS No. 18444-66-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (98.8 mM)

TargetMolReferences and Literature

3. Y-C, Hsu, T-Y, et al. Therapeutic ROS targeting of GADD45γ in the induction of G2/M arrest in primary human colorectal cancer cell lines by cucurbitacin E.[J]. Cell Death & Disease, 2014.

Related compound libraries

This product is contained In the following compound libraries:
Tobacco Monomer Library Anti-Cancer Active Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Selected Plant-Sourced Compound Library Anti-Aging Compound Library Autophagy Compound Library Inhibitor Library Kinase Inhibitor Library NO PAINS Compound Library Cell Cycle Compound Library

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Keywords

Cucurbitacin E 18444-66-1 Autophagy Cell Cycle/Checkpoint CDK α-Elaterin Cyclin dependent kinase inhibit α-Elaterine Inhibitor inhibitor

 

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