nanomolar — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T64320	ML251		Glucokinase , Parasite
	ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase[1]. ML251 inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1]...		Glucokinase , Parasite
T8507	MAC-545496		Antibacterial
	MAC-545496 is a glycopeptide-resistance-associated protein R (GraR) inhibitor, is an antivirulence agent.		Antibacterial
T6322	Copanlisib	BAY 80-6946	Apoptosis , PI3K
	Copanlisib (BAY 80-6946) is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor c...		Apoptosis , PI3K
T14998	Copanlisib dihydrochloride	BAY 80-6946 dihydrochloride	Apoptosis , PI3K , mTOR
	Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is an ATP-competitive pan-class I PI3K inhibitor (IC50s: 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ). Copanlisib dihydrochloride has super...		Apoptosis , PI3K , mTOR
T6931	PD0166285	PD-166285	Apoptosis , Wee1 , Chk
	PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.		Apoptosis , Wee1 , Chk
T26600	Alpidem	Ananxyl	GABA Receptor
	Alpidem (Ananxyl) is an anxiolytic drug from the imidazopyridine family. Alpidem does not produce sedative effects at normal doses, and is instead used specifically for the treatment of anxiety. Alpidem has nanomolar bin...		GABA Receptor
T24040	ERDRP-0519	ERDRP0519,ERDRP 0519	Antiviral
	ERDRP-0519 is an orally bioavailable small-molecule inhibitor of the Measles virus (MeV) polymerase. It effectively prevents measles disease in squirrel monkeys (Saimiri sciureus) and exhibits potent inhibition of morbil...		Antiviral
T2300	AZD1208		Apoptosis , Pim , Autophagy
	AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.		Apoptosis , Pim , Autophagy
TQ0019	RR6		Others
	RR6 acts as a selective, reversible, and competitive vanin inhibitor at nanomolar concentration.		Others
T8701	GRP-60367		Others
	GRP-60367 is the first small molecule rabies virus (RABV) entry inhibitor, which has nanomolar effect on some RABV strains.		Others
T8827	EMAC10101d		Carbonic Anhydrase
	compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an inhibitory activity in the low nanomolar range.		Carbonic Anhydrase
T16392	ONC206		Dopamine Receptor
	ONC206, an analogue of the TRAIL inducer ONC201, acts as a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations and possesses broad-spectrum anti-tumor activity.		Dopamine Receptor
T39039	FSCPX		Adenosine Receptor
	FSCPX is a potent and selective irreversible antagonist of the A1 adenosine receptor (A1AR), exhibiting low nanomolar binding potency. Additionally, FSCPX can effectively decrease the interstitial adenosine level in the ...		Adenosine Receptor
T3582	BTZ043		Antibacterial , Antibiotic , DprE1
	BTZ043 is a DprE1 inhibitor with nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.		Antibacterial , Antibiotic , DprE1
T9295	BLU-263		c-Kit
	BLU-263 is an investigational, potent, and selective oral small molecule inhibitor of KIT with sub-nanomolar potency against D816V-mutant KIT.		c-Kit
T14501	BAY-2402234		Dehydrogenase , DNA/RNA Synthesis
	BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity.		Dehydrogenase , DNA/RNA Synthesis
T6828	ZL0420		Epigenetic Reader Domain
	ZL0420 is a potent and selective bromodomain-containing protein 4 ( BRD4 ) inhibitor with nanomolar binding affinities to bromodomains (BDs) of BRD4. ZL0420 has IC 50 values of 27 nM against BRD4 BD1 and 32 nM against B...		Epigenetic Reader Domain
T37376	PHY34		Autophagy
	PHY34 is a late stage autophagy inhibitor with nanomolar level inhibitory effect and anti-tumor activity against high-grade serous ovarian cancer (HGSOC) in vivo.		Autophagy
T10533	BI-2852		Ras
	BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.		Ras
T12328	OSMI-4		Others
	OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor (EC50 of 3 μM in cells), which can be used to study OGT inhibition in different human cell lines.		Others