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MAC-545496

Catalog No. T8507 CAS 838810-96-1

MAC-545496 is a glycopeptide-resistance-associated protein R (GraR) inhibitor, is an antivirulence agent.

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MAC-545496, CAS 838810-96-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 36.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 59.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 178.00
50 mg	In stock	$ 289.00
100 mg	In stock	$ 428.00
200 mg	In stock	$ 623.00
1 mL * 10 mM (in DMSO)	In stock	$ 66.00

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Purity: 99.33%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

MAC-545496 is a glycopeptide-resistance-associated protein R (GraR) inhibitor, is an antivirulence agent.

In vitro

MAC-545496 could also serve as an antivirulence agent alone;?it attenuates MRSA virulence in Galleria mellonella larvae.?MAC-545496 inhibits biofilm formation and abrogates intracellular survival in macrophages.?Mechanistic characterization revealed MAC-545496 to be a nanomolar inhibitor of GraR, a regulator that responds to cell-envelope stress and is an important virulence factor and determinant of antibiotic resistance.

Molecular Weight	419.89
Formula	C18H18ClN5O3S
CAS No.	838810-96-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (595.39 mM), Sonication is recommended.

References and Literature

1. El-Halfawy OM, et al. Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA. Nat Chem Biol. 2019 Nov 25.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library NO PAINS Compound Library Immunology/Inflammation Compound Library Anti-Infection Compound Library Beta-Lactam Compound Library Anti-Bacterial Compound Library Bioactive Compounds Library Max Antibiotics Library Drug-induced Liver Injury (DILI) Compound Library

Related Products

Related compounds with same targets

Garenoxacin Xanthone Zinc pyrithione Saccharin Cymen-ar-ol Homoembelin Cefazolin sodium PGLa acetate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MAC-545496 838810-96-1 Microbiology/Virology Antibacterial Bacterial S. aureus Antivirulence Inhibitor mprF nanomolar GraR MAC 545496 MRSA survival inhibit biofilm virulence MAC545496 β-lactam inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.