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ERDRP-0519

Catalog No. T24040 CAS 1374006-96-8

Synonyms: ERDRP0519, ERDRP 0519

ERDRP-0519 is an orally bioavailable small-molecule inhibitor of the Measles virus (MeV) polymerase. It effectively prevents measles disease in squirrel monkeys (Saimiri sciureus) and exhibits potent inhibition of morbilliviruses in the nanomolar range.

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ERDRP-0519, CAS 1374006-96-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 139.00
5 mg	In stock	$ 347.00
10 mg	In stock	$ 488.00
25 mg	In stock	$ 785.00
50 mg	In stock	$ 1,120.00
100 mg	In stock	$ 1,480.00
1 mL * 10 mM (in DMSO)	In stock	$ 382.00

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Purity: 98.64%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ERDRP-0519 is an orally bioavailable small-molecule inhibitor of the Measles virus (MeV) polymerase. It effectively prevents measles disease in squirrel monkeys (Saimiri sciureus) and exhibits potent inhibition of morbilliviruses in the nanomolar range.
In vitro	ERDRP-0519 exhibits potency against a panel of Measles virus (MeV) isolates with EC50s of 0.07- 0.3 µM[1]. ERDRP-0519 exhibits potency against MeV and related pathogens of the Morbillivirus genus, such as canine distemper virus (CDV)[3].
In vivo	A single-dose pharmacokinetic study was conducted in squirrel monkeys through oral administration of ERDRP-0519 at a dose of 50 mg/kg, with blood samples collected at seven predetermined time points following the dose. The peak serum concentrations of ERDRP-0519 were observed approximately 2 hours post-administration, reaching a maximum (Cmax) of 3.27 µM.

Synonyms	ERDRP0519, ERDRP 0519
Molecular Weight	529.58
Formula	C23H30F3N5O4S
CAS No.	1374006-96-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (169.9 mM), Sonication is recommended.

References and Literature

1. Stefanie A Krumm, et al. An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model. Sci Transl Med. 2014 Apr 16;6(232):232ra52. 2. Richard K Plemper. Measles Resurgence and Drug Development. Curr Opin Virol. 2020 Apr;41:8-17. 3. Kevin Wittwer, et al. Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding. Nat Commun. 2021 Sep 2;12(1):5233.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Viral Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ERDRP-0519 1374006-96-8 Immunology/Inflammation Antiviral ERDRP0519 ERDRP 0519 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.