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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T40130 | Nur77 modulator 1 | Nur77 modulator 1 | Others |
Nur77 modulator 1 is a good Nur77 binder (KD = 3.58 μM). Nur77 modulator 1 up-regulates Nur77 expression, mediates sub-cellular localization of Nur77, induces Nur77-dependent ER stress and autophagy, and results in cell ... | |||
T21083 | TFIIH Modulator-19 | TFIIH Modulator19,TFIIH Modulator 19 | Others |
TFIIH Modulator-19 induces the dimerization of trichothiodystrophy group A protein to modulate TFIIH transcriptional activity. | |||
T40997 | GLP-1R modulator C16 | GLP-1R modulator C16 | Glucagon Receptor |
GLP-1R modulator C16 is a variable modulator that significantly increases the binding affinity of GLP-4. | |||
T60063 | Fluorogen binding modulator-1 | Fluorogen binding modulator-1 | Others |
Fluorogen binding modulator-1 (Fluorogen binding modulator-1) is a nonfluorescent inhibitors of Fluorogen–Fluorogen Activating Protein Binding Pairn. | |||
T40279 | GLP-1R modulator L7-028 | GLP-1R modulator L7-028 | cAMP , Glucagon Receptor |
GLP-1R modulator L7-028 is a variant modulator that enhances affinity for GLP-1 and cAMP signaling. | |||
T12821 | S1PR1 modulator 1 | LPL Receptor | |
S1PR1 modulator 1 is a selective inhibitor of S1PR1 with a pIC50 of 7.6. | |||
T10696 | CB2 modulator 1 | Cannabinoid Receptor | |
CB2 modulator 1 is a potent CB2 modulator. It can be used for the research for immune disorders, osteoporosis, inflammation, renal ischemia. | |||
T10168 | 5-HT1A modulator 1 | 5-HT1Amodulator1 | Phospholipase , Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor |
5-HT1A modulator 1 displays very high affinities for the 5-HT1A, α1-adrenergic receptor, and D2 receptor (IC50s = 2 nM, 10 nM, and 40 nM). | |||
T12922 | Sirtuin modulator 1 | SRT3025 Hydrochloride | Sirtuin |
Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM. | |||
T37734 | AMPA receptor modulator-2 | GluR | |
AMPA receptor modulator-2 (Example 134) is a AMPA receptor modulator, with a pIC50 of 10.1 for TARPγ2 dependent AMPA receptor[1]. pIC50 = -lgIC50. [1]. BERRY CYNTHIA G B (US), et al. AZABENZIMIDAZOLES AND THEIR USE AS AM... | |||
T67832 | ALDH2 modulator 1 | Dehydrogenase | |
ALDH2 modulator 1 is a potent and orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice. | |||
T11458 | GPR40/FFAR1 modulator 1 | GPR | |
GPR40/FFAR1 modulator 1 is a Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1) agonist and allosteric modulator. | |||
T67745 | CB2R/FAAH modulator-2 | Cannabinoid Receptor , FAAH | |
CB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting at CB2R and FAAH. CB2R/FAAH modulator-2 acts as a CB2R agonist and FAAH inhibitor, the Ki values are 10.8 and 152.9 nM for CB2R and CB1R, respectively, an... | |||
T8824 | CRBN modulator-1 | WUN29654 | Others , Ligand for E3 Ligase |
CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM. | |||
T67884 | β-catenin modulator IIa-661 | Wnt/beta-catenin | |
β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity. | |||
T10101 | Calcium channel-modulator-1 | Others , Calcium Channel | |
Calcium channel-modulator-1 is a calcium channel-modulator (IC50:0.8 μM) with specialisation to block aortic constriction. | |||
T9999 | Sirtuin modulator 2 | N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide | Others , Sirtuin |
Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities. | |||
T36526 | IL-17 modulator 4 | Interleukin | |
IL-17 modulator 4 is a prodrug of IL-17 modulator 1 which is an efficacious modulator of IL-17. | |||
T67747 | CB2R/FAAH modulator-3 | Cannabinoid Receptor , FAAH | |
CB2R/FAAH modulator-3 (compound 27) is a modulator targeting at CB2R and FAAH. CB2R/FAAH modulator-3 acts as a CB2R agonist and FAAH inhibitor, the Ki values are 20.1 and 67.6 nM for CB2R and CB1R, respectively, and the ... | |||
T10307 | AMPA receptor modulator-1 | iGluR | |
AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels. |