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CB2R/FAAH modulator-2

Catalog No. T67745 CAS 2876918-68-0

CB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting at CB2R and FAAH. CB2R/FAAH modulator-2 acts as a CB2R agonist and FAAH inhibitor, the Ki values are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 has studies research value related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.

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CB2R/FAAH modulator-2, CAS 2876918-68-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

CB2R/FAAH modulator-2 (compound 26)(10 μ M) can reduce the production of pro-inflammatory cytokine TNF α、 IFN- γ、 IL-1 β and IL6 in unstimulated monocytes and macrophages[1].

Molecular Weight	367.52
Formula	C24H33NO2
CAS No.	2876918-68-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 3.68 mg/mL (10 mM), Need ultrasound

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Francesca Intranuovo, et al. Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66(1):235-250.

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Keywords

CB2R/FAAH modulator-2 2876918-68-0 GPCR/G Protein Metabolism Neuroscience FAAH Cannabinoid Receptor CB2R/FAAH modulator2 Inhibitor inhibitor inhibit

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