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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T41078 | Lipopolysaccharides, Escherichiacoli (11C) | LPS E. coli O55:B5,Lipopolysaccharide, E. coli O111:B4 | Others |
Lipopolysaccharides, Escherichiacoli (11C) (LPS E. coli O55:B5), a macromolecular component of the outer membrane of Gram-negative bacteria, is composed of three regions: a lipid A, an oligosaccharide core, and an O-spec... | |||
T37859 | SY-640 | Endogenous Metabolite | |
SY-640 is an Acetamide derivative. SY-640 exhibits potent hepatoprotective effect. SY-640 reduces liver injury in mice induced by Propionibacterium acnes and Lipopolysaccharide. | |||
T8235 | L-732138 | Neurokinin receptor | |
L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM) | |||
T21785 | AG957 | Bcr-Abl | |
Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1]. | |||
T2923 | Apremilast | CC-10004 | Apoptosis , TNF , PDE |
Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities. | |||
T16501 | PF-3644022 | p38 MAPK , Serine Protease , MAPK | |
PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhib... | |||
TN1291 | 7,3',4'-Tri-O-methylluteolin | 5-Hydroxy-3',4',7-trimethoxyflavone | TNF , COX , Interleukin |
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC value of 19.0 ug/ml | |||
T0947 | Dexamethasone acetate | Dexamethasone 21-acetate,Dexamethason acetate,NSC 39471 | Glucocorticoid Receptor , Mitophagy , IL Receptor , Annexin A , NOS , Antibacterial , Autophagy |
Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexa... | |||
T21233 | Dihydrolipoic acid | Reduced thioctic acid,Reduced lipoic acid,DHLA,USAF XR-12,6,8-Dihydrothioctic acid | Antioxidant |
Dihydrolipoic acid (USAF XR-12), a dithiol-containing carboxylic acid, acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including peroxynitirite, hydroxyl radicals, hydr... | |||
T11855 | Lipopolysaccharides | LPS | Others |
Lipopolysaccharides (LPS) is a natural product, an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides are highly immunogenic antigens that enhance the immune res... | |||
TN1021 | Secologanic acid | NO Synthase | |
Secologanic acid is a plant growth inhibitor, it shows inhibition of nitric oxide production in lipopolysaccharide-activated macrophages. | |||
T5101 | BW-A 78U | BW-A78U | PDE |
BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release. | |||
TWS0704 | N-Methylnuciferine | Others | |
N-Methylnuciferine is an alkaloid from Lotus Plumule that ameliorates lipopolysaccharide-induced depression-like behavior. | |||
T5798 | Euphorbia Factor L2 | euphorbiafactor L2 | Apoptosis , NF-κB |
Euphorbia Factor L2 alleviates lipopolysaccharide-induced acute lung injury and inflammation through inhibits NF-κB activation. | |||
T29352 | 2-Hydroxydecanoic acid | (±)-α-hydroxy Decanoic Acid,(±)-2-hydroxy Decanoic Acid,alpha-Hydroxydecanoic acid,2-hydroxy Decylic Acid,2-Hydroxydecanoate | Others |
2-Hydroxydecanoic acid ((±)-α-hydroxy Decanoic Acid) is a fatty acid found in the lipophilic portion of the lipopolysaccharide fraction of the aerobic bacterium P. ovalis. | |||
TN1553 | Deacetyl ganoderic acid F | Others | |
Deacetyl ganoderic acid F (DeGA F), a triterpenoid extracted from Ganoderma lucidum, inhibits lipopolysaccharide (LPS)-induced inflammation in vitro and in vivo. | |||
T7053 | P-Hydroxycinnamic acid | p-Coumaric acid,p-Cumaric acid,p-Hydroxy-cinnamic acid,NSC 59260 | Thrombin , Endogenous Metabolite , Prostaglandin Receptor |
p-Hydroxycinnamic acid (NSC-59260) can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively. | |||
TN2167 | Rutaevin | Reactive Oxygen Species , NO Synthase | |
Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflammatory agent. | |||
T5660 | Menthone | IL Receptor , TNF , NF-κB , Parasite | |
Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha),as well as nuclear factor k... | |||
TN1933 | Mitraphylline | IL Receptor , TNF , NF-κB | |
Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-mediated activation of primary human neutrophils. |