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BW-A 78U
🥰Excellent
Catalog No. T5101Cas No. 101155-02-6
Alias BW-A78U
BW-A 78U, a PDE4 inhibitor (IC50: 3 μM), does not inhibit lipopolysaccharide (LPS)-induced TNF-α release.
BW-A 78U
🥰Excellent
Purity: 99.45%
Catalog No. T5101Alias BW-A78UCas No. 101155-02-6
BW-A 78U, a PDE4 inhibitor (IC50: 3 μM), does not inhibit lipopolysaccharide (LPS)-induced TNF-α release.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $33 | In Stock | |
| 5 mg | $103 | In Stock | |
| 10 mg | $155 | In Stock | |
| 25 mg | $262 | In Stock | |
| 50 mg | $377 | In Stock | |
| 100 mg | $533 | In Stock | |
| 200 mg | $732 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $37 | In Stock |
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Purity:99.45%
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Product Introduction
Bioactivity
Chemical Properties
| Description | BW-A 78U, a PDE4 inhibitor (IC50: 3 μM), does not inhibit lipopolysaccharide (LPS)-induced TNF-α release. |
| Targets&IC50 | PDE4:3 μM |
| Cell Research | Mononuclear cells were incubated for 30 min with BW-A 78U (0.01-10 μM). The cells were then stimulated with lipopolysaccharide (10 μg/mL) overnight at 37°C in an atmosphere of 5% CO2 at 100% humidity. Cell-free supernatants were collected, centrifuged (2000 g), and stored frozen at -20°C before TNF-α determination. TNF-α concentrations in cell culture supernatants were determined by specific ELISA using a commercial kit. The sensitivity of the assay was 1 pg/mL. The absorbance at 450 nm was assessed with an ELISA reader. |
| Synonyms | BW-A78U |
| Molecular Weight | 257.27 |
| Formula | C13H12FN5 |
| Cas No. | 101155-02-6 |
| Smiles | CNc1ncnc2n(Cc3ccccc3F)cnc12 |
| Relative Density. | 1.36g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (174.91 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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