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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12728 | RIP2 Kinase Inhibitor 3 | Others , RIP kinase | |
RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM. | |||
T64350 | Casein kinase 1δ-IN-3 | Casein Kinase | |
Casein kinase 1δ-IN-3 (Casein kinase 1δ-IN-3) (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M. | |||
T5524 | Aurora kinase inhibitor-3 | Aurora Kinase Inhibitor III | Aurora Kinase |
Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR. | |||
TP1509 | Casein Kinase Substrates 3 | ||
Casein Kinase Substrates 3 is a substrate of casein kinase. | |||
T1965 | Bikinin | Abrasin | Others , GSK-3 |
Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor. | |||
T14069 | A-3 hydrochloride | CaMK , Casein Kinase , PKA , PKC | |
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectiv... | |||
T11942 | MAP4K4-IN-3 | Compound 17 | MAPK |
MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase. | |||
T5200 | Indirubin-3'-monoxime | Indirubin-3'-oxime | GSK-3 , Lipoxygenase , CDK |
Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E). | |||
T2836 | Isorhamnetin | 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin | MEK , PI3K , Endogenous Metabolite |
Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD... | |||
T21966 | MeBIO | GSK-3 , Aryl Hydrocarbon Receptor , CDK | |
MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β. | |||
T9138 | Indirubin-3′-oxime | Indirubin-3'-monoxime | GSK-3 , CDK , JNK |
Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease. | |||
T11447 | GNF4877 | GSK-3 , DYRK | |
GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation cells. | |||
T9987 | GSK3-IN-1 | GSK-3 | |
GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor. | |||
T5956 | VP3.15 dihydrobromide | GSK-3 , PDE | |
VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE7- glycogen synthase kinase (GSK)3 inhibitor(with IC50s of 1.59 μM , 0.88 μM,respectively.) | |||
T1755 | LY2090314 | GSK-3 | |
LY2090314, an effective GSK-3α/β inhibitor (IC50: 1.5 nM/0.9 nM), may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, a... | |||
T1957 | AZD2858 | GSK-3 | |
AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway. | |||
T1741 | AZD1080 | GSK-3 | |
AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor. | |||
T10202 | A 1070722 | GSK-3 | |
A 1070722 is a potent and selective GSK-3 inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. It can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for... | |||
T2166 | TWS119 | GSK-3 , Autophagy | |
TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation | |||
T9034 | MK2-IN-3 | MK2 Inhibitor III | MAPK |
MK2-IN-3 (MK2 Inhibitor III) is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatment of rheumatoid arthritis |