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Aurora kinase inhibitor-3

Catalog No. T5524 CAS 879127-16-9

Synonyms: Aurora Kinase Inhibitor III

Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR.

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Aurora kinase inhibitor-3 Chemical Structure

Aurora kinase inhibitor-3, CAS 879127-16-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 71.00
2 mg	In stock	$ 98.00
5 mg	In stock	$ 198.00
10 mg	In stock	$ 313.00
25 mg	In stock	$ 526.00
50 mg	In stock	$ 748.00
100 mg	In stock	$ 987.00
200 mg	In stock	$ 1,380.00
1 mL * 10 mM (in DMSO)	In stock	$ 226.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR.
Targets&IC50	Aurora A:42 nM

Synonyms	Aurora Kinase Inhibitor III
Molecular Weight	413.4
Formula	C21H18F3N5O
CAS No.	879127-16-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (120.9 mM)

References and Literature

1. Zhang Q , Liu Y , Gao F , et al. Discovery of EGFR Selective 4,6-Disubstituted Pyrimidines from a Combinatorial Kinase-Directed Heterocycle Library[J]. Journal of the American Chemical Society, 2006, 128(7):2182-2183. 2. Tari L W , Hoffman I D , Bensen D C , et al. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors[J]. Bioorganic and Medicinal Chemistry Letters, 2007, 17(3):688-691.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Bioactive Compounds Library Max Anti-Aging Compound Library Epigenetics Compound Library Autophagy Compound Library Cell Cycle Compound Library Anti-Cancer Compound Library NO PAINS Compound Library Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Aurora kinase inhibitor-3 879127-16-9 Cell Cycle/Checkpoint Chromatin/Epigenetic Aurora Kinase Aurora kinase inhibitor 3 Aurora kinase inhibitor3 Inhibitor inhibit Aurora Kinase Inhibitor III inhibitor

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