Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A 1070722 is a potent and selective GSK-3 inhibitor, shows high affinity GSK-3α(Ki = 0.6 nM) and GSK-3β(Ki = 0.6 nM). It can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 63.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 197.00 | |
50 mg | In stock | $ 357.00 | |
100 mg | In stock | $ 533.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 68.00 |
Description | A 1070722 is a potent and selective GSK-3 inhibitor, shows high affinity GSK-3α(Ki = 0.6 nM) and GSK-3β(Ki = 0.6 nM). It can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain. |
Targets&IC50 | GSK-3α:0.6 nM (ki), GSK-3β:0.6 nM (ki) |
In vivo | PET imaging experiments in anesthetized vervet/African green monkey exhibited that A 1070722 penetrated the blood-brain barrier (BBB) and accumulated in brain regions, with highest radioactivity binding in frontal cortex followed by parietal cortex and anterior cingulate, and with the lowest bindings found in caudate, putamen, and thalamus, similarly to the known distribution of GSK-3 in human brain[1]. |
Molecular Weight | 362.31 |
Formula | C17H13F3N4O2 |
CAS No. | 1384424-80-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.33 mg/mL (230.00 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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A 1070722 1384424-80-9 PI3K/Akt/mTOR signaling Stem Cells GSK-3 Glycogen synthase kinase-3 inhibit Inhibitor A1070722 Glycogen synthase kinase 3 A-1070722 inhibitor