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TWS119

Catalog No. T2166 CAS 601514-19-6

TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation

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TWS119, CAS 601514-19-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 43.00
10 mg	In stock	$ 70.00
25 mg	In stock	$ 137.00
50 mg	In stock	$ 253.00
100 mg	In stock	$ 437.00
1 mL * 10 mM (in DMSO)	In stock	$ 47.00

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Purity: 99.13%

Purity: 98.02%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation
Targets&IC50	GSK-3β:30 nM
In vivo	A cell population that expressed low levels of CD44 and high levels of CD62L on the cell surface when 30 mg/kg of TWS119 is administered. [4]

Molecular Weight	318.33
Formula	C18H14N4O2
CAS No.	601514-19-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 60 mg/mL (188.5 mM)

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ding S, et al, Pro Natl Acad Sci U S A, 2003, 100(13), 7632-7637. 2. Ding S, et al, Nat Biotechnol, 2004, 22(7), 833-840. 3. Kordes C, et al, Biochem Biophys Res Commun, 2008, 367(1), 116-123. 4. Gattinoni L, et al, Nat Mediicine, 2009, 15(7), 808-813. 5. Muralidharan S, et al, J Immunol, 2011, 187(10), 5521-5532. 6. Wang W, et al. GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats. Mol Neurobiol. 2016 Dec;53(10):7028-7036. Epub 2015 Dec 15. 7. Chen YQ, et al. Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human γδT cells against colon cancer. Exp Cell Res. 2017 Nov 16. pii: S0014-4827(17)30587-6.

Related compound libraries

This product is contained In the following compound libraries：

Neuronal Differentiation Compound Library Stem Cell Differentiation Compound Library Anti-Cancer Metabolism Compound Library Anti-Cancer Compound Library HIF-1 Signaling Pathway Compound Library Anti-Obesity Compound Library Anti-Diabetic Compound Library Glycolysis Compound Library Inhibitor Library Anti-Lung Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TWS119 601514-19-6 Autophagy PI3K/Akt/mTOR signaling Stem Cells GSK-3 TWS 119 inhibit Glycogen synthase kinase-3 Inhibitor TWS-119 Glycogen synthase kinase 3 inhibitor

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