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MAP4K4-IN-3 (Alias: Compound 17)

Name: MAP4K4-IN-3
Brand: TargetMol
SKU: T11942
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T11942 Copy Product Info

Purity: 98.07%

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MAP4K4-IN-3 (Compound 17), a serine/threonine protein kinase, may be a viable target for antidiabetic agents.

MAP4K4-IN-3

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Catalog No. T11942

Alias Compound 17

MAP4K4-IN-3 (Compound 17), a serine/threonine protein kinase, may be a viable target for antidiabetic agents.

Cas No. 1811510-58-3

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Pack Size	Price	USA Stock	Global Stock
5 mg	$39	In Stock	In Stock
10 mg	$72	In Stock	In Stock
25 mg	$155	In Stock	In Stock
50 mg	$247	In Stock	In Stock
100 mg	$393	In Stock	In Stock
200 mg	$582	-	In Stock
500 mg	$885	-	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.07%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	MAP4K4-IN-3 (Compound 17), a serine/threonine protein kinase, may be a viable target for antidiabetic agents.
Targets&IC50	MAP4K4:14.9 nM
In vitro	MAP4K4-IN-3, Antidiabetic agent.MAP4K4-IN-3 is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay.
In vivo	Administering MAP4K4-IN-3 (Compound 2; 25 mg/kg, b.i.d.) orally to telemetered rats over a period of five days induces several adverse reactions. Cardiovascular measurements reveal a significant increase in maximal heart rate by 25 beats per minute (bpm) compared to control groups upon treatment with MAP4K4-IN-3[2]. Additionally, there are noticeable declines in body weight (7%) and an increase in body temperature (0.4°C) against control values throughout the study.
Synonyms	Compound 17

Chemical Properties

Molecular Weight	297.74
Formula	C₁₅H₁₂ClN₅
Cas No.	1811510-58-3
Smiles	Nc1ncc(cn1)-c1cnc(N)c(c1)-c1ccc(Cl)cc1
Relative Density.	1.377 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (26.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3586 mL	16.7932 mL	33.5864 mL	167.9318 mL
5 mM	0.6717 mL	3.3586 mL	6.7173 mL	33.5864 mL
10 mM	0.3359 mL	1.6793 mL	3.3586 mL	16.7932 mL
20 mM	0.1679 mL	0.8397 mL	1.6793 mL	8.3966 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc