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Bikinin

Name: Bikinin
Brand: TargetMol
SKU: T1965
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1965Cas No. 188011-69-0

Alias Abrasin

Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.

Bikinin

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Purity: 99.86%

Catalog No. T1965Alias AbrasinCas No. 188011-69-0

Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.

Pack Size	Price	Availability
10 mg	$39	In Stock
25 mg	$70	In Stock
50 mg	$122	In Stock
100 mg	$197	In Stock
200 mg	$293	In Stock
500 mg	$497	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:99.86%

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.
In vitro	Bikinin directly inhibited BIN2 in Arabidopsis GSK-3s and activated oleuropein steroid-dependent gene expression.Bikinin also inhibited RD26 expression and, in the case of RD26pro:GUS, NaCl (150 mM)-induced GUS activity.
In vivo	Bikinin directly inhibited BIN2 in Arabidopsis GSK-3s and activated oleuropein steroid-dependent gene expression.Bikinin also inhibited RD26 expression and, in the case of RD26pro:GUS, NaCl (150 mM)-induced GUS activity.
Synonyms	Abrasin

Chemical Properties

Molecular Weight	273.08
Formula	C₉H₉BrN₂O₃
Cas No.	188011-69-0
Smiles	OC(=O)CCC(=O)NC1=NC=C(Br)C=C1
Relative Density.	1.711 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 45 mg/mL (164.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6619 mL	18.3097 mL	36.6193 mL	183.0965 mL
5 mM	0.7324 mL	3.6619 mL	7.3239 mL	36.6193 mL
10 mM	0.3662 mL	1.8310 mL	3.6619 mL	18.3097 mL
20 mM	0.1831 mL	0.9155 mL	1.8310 mL	9.1548 mL
50 mM	0.0732 mL	0.3662 mL	0.7324 mL	3.6619 mL
100 mM	0.0366 mL	0.1831 mL	0.3662 mL	1.8310 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc