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Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LDL via inhibition of lectin-like ox-LDL receptor-1 upregulation, interference of ox-LDL-mediated intracellular signaling pathway (p38 MAPK activation, NF-kappaB nuclear translocation, eNOS expression) and the antioxidant activity of isorhamnetin. Isorhamnetin prevents endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II. Isorhamnetin appears to be a potent drug against esophageal cancer due to it's in vitro potential to not only inhibit proliferation but also induce apoptosis of Eca-109 cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 75.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 247.00 | |
50 mg | In stock | $ 413.00 | |
100 mg | In stock | $ 590.00 | |
500 mg | In stock | $ 1,270.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 78.00 |
Description | Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LDL via inhibition of lectin-like ox-LDL receptor-1 upregulation, interference of ox-LDL-mediated intracellular signaling pathway (p38MAPK activation, NF-kappaB nuclear translocation, eNOS expression) and the antioxidant activity of isorhamnetin. Isorhamnetin prevents endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II. Isorhamnetin appears to be a potent drug against esophageal cancer due to it's in vitro potential to not only inhibit proliferation but also induce apoptosis of Eca-109 cells. |
Source |
Synonyms | 3-methylquercetin, 3'-Methylquercetin, Isorhamnetol, 3'-Methoxyquercetin |
Molecular Weight | 316.26 |
Formula | C16H12O7 |
CAS No. | 480-19-3 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (189.71 mM)
You can also refer to dose conversion for different animals. More
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Isorhamnetin 480-19-3 MAPK Metabolism PI3K/Akt/mTOR signaling PI3K MEK Endogenous Metabolite 3-methylquercetin 3'-Methylquercetin Isorhamnetol MAP2K Phosphoinositide 3-kinase MAPKK inhibit Mitogen-activated protein kinase kinase Inhibitor 3'-Methoxyquercetin inhibitor