hyperlipidemia — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2824	Pedunculoside		Others , Fatty Acid Synthase
	Pedunculoside is extracted from Ilex rotunda Thunb.		Others , Fatty Acid Synthase
T3941	Choline Fenofibrate	Trilipix,ABT-335	P450 , COX , PPAR
	Choline Fenofibrate (Trilipix) is a choline formulation of fenofibrate, a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity.		P450 , COX , PPAR
T2321	Protodioscin	Furostanol I	Androgen Receptor , Endogenous Metabolite
	Protodioscin (Furostanol I) is a major steroidal saponin in dioscoreae rhizome, with anti-hyperlipidemia, anti-cancer properties.		Androgen Receptor , Endogenous Metabolite
T4628	Seladelpar	MBX 8025	PPAR
	Seladelpar (MBX 8025) has been used in trials studying the treatment of Hyperlipidemia.		PPAR
T27832	Lifibrol	U 83860,K-12148,K-12.148,U-83860,K12148	Lipid
	Lifibrol (U-83860) is an inhibitor of cholesterol synthesis.Lifibrol has anticholesterol and hypolipidemic properties and promotes the conversion of LDL Apo B-100 in patients with hypercholesterolemia and mixed hyperlipi...		Lipid
T24865	Tenivastatin	L-654969,L654969,Simvastatin acid,L 654969,Simvastatin hydroxy acid	ROS , HMG-CoA Reductase
	Tenivastatin (Simvastatin acid) is an anti-hyperlipidemic HMG-CoA reductase inhibitor that inhibits the production of reactive oxygen species (ROS) and can be used in the study of primary hyperlipidemia.		ROS , HMG-CoA Reductase
T1162	Acipimox	Olbemox,K-9321	Others
	Acipimox (K-9321) is a niacin derivative and nicotinic acid analog with activity as a hypolipidemic agent. Acipimox has special application for the treatment of hyperlipidemia in non-insulin-dependent diabetic patients.		Others
T27245L	Eflucimibe	L0081,F-12511	Acyltransferase
	Eflucimibe (L0081) is an acyl coenzyme A: cholesterol acyltransferase inhibitor for the treatment of cardiovascular disease and endocrine and metabolic disorders, and can be used to study atherosclerosis and hyperlipidem...		Acyltransferase
T1604	Tiratricol	3,3',5-Triiodothyroacetic acid	Thyroid hormone receptor(THR)
	Tiratricol (3,3',5-Triiodothyroacetic acid) is a metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of A...		Thyroid hormone receptor(THR)
T67974	Berberine ursodeoxycholate	HTD1801,BUDCA
	Berberine ursodeoxycholate (HTD1801) is an orally effective hypolipidemic agent, an ionic salt of Berberine and Ursodeoxycholic acid.Berberine ursodeoxycholate has a wide range of metabolic activity and significantly red...
T72025	PCSK9-IN-10		Serine/threonin kinase
	PCSK9-IN-10, a potent and orally active inhibitor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), exhibits a half-maximal inhibitory concentration (IC50) of 6.4 µM. By enhancing the expression of Low-Density Li...		Serine/threonin kinase
TN1011	Rhodionin		P450 , AChE
	Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs; they can significantly suppress the elevation of ...		P450 , AChE
T3779	Crocin II	Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B	Caspase , COX , NO Synthase
	Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expres...		Caspase , COX , NO Synthase
T3123	Allicin		ERK , IL Receptor , Others , IκB/IKK , p38 MAPK , TNF , ROS , Caspase , Antifection
	Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth mus...
T26819	Binifibrate	WAC104,WAC 104,Antopal,WAC-104,Biniwas
	Binifibrate is a hyperlipemiant drug used for the treatment of hyperlipidemia.
T28825	Sodelglitazar	GW677954,GSK-677954
	Sodelglitazar, a PPAR agonist, is used potentially for the treatment of hyperlipidemia and type 2 diabetes.
T30110	AR 12456	AR12456,AR-12456
	AR-12456 is a Trapidil derivative that prevents serum hyperlipidemia in guinea pigs.
T23611	Acetiromate	Adecol
	Acetiromate is a drug of antilipidemic. It is used to treat hyperlipidemia.
T28820	SMP-797 HCl	SMP-797,SMP 797,SMP797
	SMP-797 HCl, an ACAT (acyl-CoA-cholesterol acyltransferase) inhibitor, is used potentially for the treatment of Hyperlipidemia.
T11914	LY88074 Trimethyl ether		Others
	LY88074 Trimethyl ether is useful for inhibiting various conditions associated with estrogen deprivation syndrome, such as osteoporosis and hyperlipidemia.		Others