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Rhodionin

Catalog No. TN1011 CAS 85571-15-9

Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs; they can significantly suppress the elevation of the postprandial blood triglyceride level, suggests that they may be to the treatment of lifestyle-related diseases such as hyperlipidemia and exogeneous obesity and to health foods.

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Rhodionin, CAS 85571-15-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 109.00
5 mg	In stock	$ 277.00
10 mg	In stock	$ 473.00
25 mg	In stock	$ 759.00
50 mg	In stock	$ 987.00
100 mg	In stock	$ 1,380.00
1 mL * 10 mM (in DMSO)	In stock	$ 273.00

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Purity: 99.24%

Purity: 98.50%

Biological Description

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Description	Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs; they can significantly suppress the elevation of the postprandial blood triglyceride level, suggests that they may be to the treatment of lifestyle-related diseases such as hyperlipidemia and exogeneous obesity and to health foods.
Targets&IC50	DPPH free radical scavenging:19.49 μM (IC50), AChE:57.50-2.43 μg/mL (IC50), CYP2D6:0.761 μM (IC50)
In vitro	Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.In this study, 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity and nitrotetrazolium blue chloride (NBT) superoxide scavenging activity were measured to assess the antioxidant activity of the components from RRS. DPPH has the ability to easily accept hydrogen atoms because it contains an unstable element, the hydrazyl nitrogen, therefore, antioxidant activity can be measured because DPPH loses its violet color when it receives hydrogens from antioxidants. Additionally, NBT has the ability to easily receive superoxide because it contains unstable anions. Therefore, antioxidant activity may be measured when NBT loses its yellow color upon reaction with abundant superoxide. Among the compounds from RRS, 7(Rhodionin) and 8 exhibited the most potent DPPH free radical scavenging activities, with IC50 values of 19.49 ± 0.21 and 27.77 ± 0.61 μM, respectively, compared to the positive control, L-ascorbic acid (IC50 = 32.89 ± 0.70 μM). The other compounds did not exhibit activities in this assay up to 100 μM (Table 2).
Source	Natural Products > Crassulaceae > Rhodiola

Molecular Weight	448.38
Formula	C21H20O11
CAS No.	85571-15-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (111.51 mM)

References and Literature

1. The antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of Rhodiola sachalinensis A. BOR.Molecules. 2012 Sep 27;17(10):11484-94.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Polyphenolic Natural Product Library Anti-Obesity Compound Library Natural Product Library Selected Plant-Sourced Compound Library Natural Product Library for HTS Traditional Chinese Medicine Monomer Library Traditional Mongolian Medicine Compound Library Chinese Pharmacopoeia Natural Product Library Anti-Inflammatory Traditional Chinese Medicine Compound Library

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Keywords

Rhodionin 85571-15-9 Metabolism Neuroscience P450 AChE Inhibitor inhibit Cholinesterase (ChE) inhibitor

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