hippocampal — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T20993	Memantine		Others
	Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by ...		Others
T23515	VU-29	VU 29	GluR
	VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM).		GluR
T2210	Genipin	(+)-Genipin	Others , Autophagy
	Genipin ((+)-Genipin), an active aglycone derived from an iridoid glycoside called geniposide, is found in the fruit of Gardenia jasminoides Ellis.		Others , Autophagy
T3479	(RS)-MCPG	alpha-MCPG,(±)-MCPG	GluR
	(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.		GluR
T0084	Moclobemide	Ro111163	MAO , Monoamine Oxidase
	Moclobemide (Ro111163) is a reversible inhibitor of monoamine oxidase type A; (RIMA); (see MONOAMINE OXIDASE INHIBITORS) that has antidepressive properties.		MAO , Monoamine Oxidase
T9776	TRPM4 inhibitor 8		TRP/TRPV Channel
	TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.		TRP/TRPV Channel
T23283	2-Methoxyidazoxan monohydrochloride	RX 821002 hydrochloride	Adrenergic Receptor
	L-Albizziin (2-Methoxyidazoxan monohydrochloride) is a highly potent selective antagonist of the alpha 2r adrenergic receptor, with little or no antagonistic effect on imidazoline. It has a significantly higher affinity ...		Adrenergic Receptor
TP2045	CH 275
	Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin r...
T16288	Neuropathiazol		Others
	Neuropathiazol causes neuronal differentiation of adult hippocampal neural progenitor cells.		Others
TN1038	Galgravin		Apoptosis
	Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloid beta peptide (Abeta25-35)-induced cytotoxicity, and protec...		Apoptosis
TQ0233	Traxoprodil	CP101606	NMDAR , iGluR
	Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).		NMDAR , iGluR
TP1380	Galanin (1-16), mouse, porcine, rat		Neuropeptide Y Receptor
	Galanin (1-16), mouse, porcine, rat is a hippocampal galanin receptor agonist(Kd = 3 nM) with high biological activity on locus coeruleus neurons.		Neuropeptide Y Receptor
T7516	ZD7288	ICI D7288	HCN Channel
	ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity.		HCN Channel
T23782	Benzolamide	CL-11366,W 1803,CL 11366,CL11366,W-1803	Carbonic Anhydrase
	Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.		Carbonic Anhydrase
T72063	PDCD4-IN-1
	PDCD4-IN-1, a PDCD4 inhibitor (Kd : 350 nM), promotes BDNF expression in hippocampal neuronal cells HT-22.
T30549	BMY-21502	Bms-181168,Bms 181168,Bmy 21502,Bmy21502,Bms181168	Antioxidant
	BMY-21502 is a potential cognitive enhancer that shows anti-hypoxia effects in the KCN-hypoxia model, delays the decay of hippocampal synaptic enhancement in vitro, and can be used to study Alzheimer's disease.		Antioxidant
T4912	Jatrorrhizine chloride	Yatrorhizine chloride,Neprotine chloride	Others , 5-HT Receptor , OCT , Antibacterial , AChE
	Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h...		Others , 5-HT Receptor , OCT , Antibacterial , AChE
T20797	NE-100 hydrochloride	NE100 Hydrochloride,NE 100 HCl,NE 100 Hydrochloride,NE-100 Hydrochloride,NE-100 HCl	Sigma receptor
	NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death.		Sigma receptor
T6S2115	Ginkgolide J	BN 52024,7-beta-Hydroxyginkgolide A	PDE
	Ginkgolide J (BN 52024) has neuroprotective activity, it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices.		PDE
T4S2084	3'-Methoxypuerarin	3’- Methoxy Puerarin	Antioxidant
	3'-Methoxypuerarin shows neuron protection activity, it can protect hippocampal neurons against ischemia/reperfusion injury by inhibiting apoptosis. 3'-Methoxypuerarin(3’- Methoxy Puerarin) has antioxidant activities, it...		Antioxidant