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Ginkgolide J

Catalog No. T6S2115   CAS 107438-79-9
Synonyms: BN 52024, 7-beta-Hydroxyginkgolide A

Ginkgolide J (BN 52024) has neuroprotective activity, it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices.

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Ginkgolide J Chemical Structure
Ginkgolide J, CAS 107438-79-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 92.00
5 mg In stock $ 220.00
10 mg In stock $ 325.00
25 mg In stock $ 548.00
50 mg In stock $ 788.00
100 mg In stock $ 1,080.00
1 mL * 10 mM (in DMSO) In stock $ 271.00
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Purity: 99.83%
Purity: 99.64%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ginkgolide J (BN 52024) has neuroprotective activity, it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices.
In vitro A new Ginkgo biloba extract P8A (TTL), 70% enriched with terpene trilactones, prevents A beta induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices. This neuroprotective effect is attributed in large part to Ginkgolide J that completely replicates the effect of the extract. Ginkgolide J is also capable of inhibiting cell death of rodent hippocampal neurons caused by A beta[1].
Cell Research Hippocampal cultures were treated by adding 10 μM Aβ1-42 in its oligomeric form with or without P8A, or alternatively with and without each of the individual ginkgolides and bilobalide (GA, GB, GC GJ, BB).??these compounds were dissolved in DMSO and added to the culture medium at a ratio of 1:1000 (v/v), yielding a 0.1% DMSO solution.?After 24 hrs the number of viable cells was assessed by nuclear counting.?In a separate set of experiments, viable cells were counted by using the ethidium homodimer/calcein-AM combination of vital dyes (LIVE/DEAD Viability/Cytotoxicity Kit for mammalian cells;?Invitrogen), according to the manufacturer instructions.?Values represent the mean SEM of three consecutive experiments.?Each experiment was performed in triplicate[1].
Source
Synonyms BN 52024, 7-beta-Hydroxyginkgolide A
Molecular Weight 424.4
Formula C20H24O10
CAS No. 107438-79-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (141.38 mM)

TargetMolReferences and Literature

2. Vitolo O , Gong B , Cao Z , et al. Protection against β-amyloid induced abnormal synaptic function and cell death by Ginkgolide J[J]. Neurobiology of Aging, 2009, 30(2):257-265.

Related compound libraries

This product is contained In the following compound libraries:
RO5 Drug-like Natural Product Library Natural Product Library for HTS Covalent Inhibitor Library Anti-Cardiovascular Disease Compound Library Selected Plant-Sourced Compound Library Bioactive Compound Library Human Endogenous Metabolite Compound Library Plus Terpene Natural Product Library Food as Medicine Compound Library Bioactive Compounds Library Max

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Keywords

Ginkgolide J 107438-79-9 Metabolism PDE inhibit BN 52024 7-β-Hydroxyginkgolide A BN52024 BN-52024 Inhibitor 7-beta-Hydroxyginkgolide A 7-b-Hydroxyginkgolide A inhibitor

 

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