endothelium — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3927	Phellopterin		GABA Receptor
	Phellopterin is a partial agonist of the central benzodiazepine receptors in vitro. Phellopterin shows a cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM. Phellopterin reduce TNF-alpha-induced VCA...		GABA Receptor
T3638	Leukadherin-1		Integrin , Complement System
	Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendothelial migration; reduces inflammation.		Integrin , Complement System
T4435	E7820	ER68203-00	Integrin
	E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).		Integrin
T16571	Pranidipine	OPC-13340	Calcium Channel
	Pranidipine (OPC-13340) is a novel, long-acting 1,4-dihydropyridine calcium channel blocker. It prolongs acetylcholine-induced relaxation in presence of endothelium as well as nitroglycerin-induced relaxation in absence ...		Calcium Channel
T34541	SB-209670	SB 209670	Endothelin Receptor
	SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.		Endothelin Receptor
T14942	CGP48369		RAAS
	CGP48369 is a potent angiotensin II receptor antagonist with antihypertensive effects that enhances endothelium-dependent relaxation of coronary arteries in spontaneously hypertensive rats.		RAAS
TMS2171	(±)-Naringenin	Salipurpol,Naringenine,Naringenin	Potassium Channel
	(±)-Naringenin (Naringenine) is a natural product. It displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.		Potassium Channel
T0370	Pheniramine maleate	Daneral,Inhiston,Trimetose	5-HT Receptor , Histamine Receptor
	Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re...		5-HT Receptor , Histamine Receptor
T6264	Bosentan	Actelion,Ro 47-0203,Benzenesulfonamide	Endothelin Receptor
	Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks th...		Endothelin Receptor
TP1277	Bradykinin		Endogenous Metabolite , Bradykinin Receptor
	Bradykinin is an inflammatory mediator. It is a peptide that causes blood vessels to dilate (enlarge) via the release of prostacyclin, nitric oxide, and Endothelium-Derived Hyperpolarizing Factor. Bradykinin is a physiol...		Endogenous Metabolite , Bradykinin Receptor
T38248	2-Ethylpyrazine		Endogenous Metabolite , NO Synthase
	2-Ethylpyrazine is present in roasted coffee beans and is a volatile compound .2-Ethylpyrazine induces vasodilation through the activity of endothelium-derived relaxing factors.2-Ethylpyrazine activates NO synthesis thro...		Endogenous Metabolite , NO Synthase
T4567	Sulfaphenazole	Plisulfan,Raziosulfa,Depocid,Depotsulfonamide	P450 , Antibacterial
	Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1...		P450 , Antibacterial
T4809	Pyrimidine	Metadiazine	Others , Endogenous Metabolite
	Pyrimidine (Metadiazine)s are heterocyclic, six-membered, nitrogen-containing carbon ring structures, with uracil, cytosine and thymine being the basal structures of ribose-containing nucleosides (uridine, cytidine, and ...		Others , Endogenous Metabolite
T37974	(S)-Coriolic acid	13(S)-HODE	Lipoxygenase , Mitochondrial Metabolism , PPAR
	(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, and is involved in cell proliferation and differentiation i...		Lipoxygenase , Mitochondrial Metabolism , PPAR
TN1567	Delphinidin chloride		Estrogen Receptor/ERR , VEGFR
	Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in va...		Estrogen Receptor/ERR , VEGFR
T3794	Pentagalloylglucose	Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose	Influenza Virus
	1, 2, 3, 4, 6-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) and gallic acid from Pistacia lentiscus have antimutagenic and antioxidant activities. 2. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose (PGG) possesses poten...		Influenza Virus
T27574	ZM 169369	ICI169369,ICI-169369
	ICI 169369, a 5-HT2/5-HT1C antagonist, can evoke endothelium-dependent relaxation in rabbit aorta.
T83164	Adrenomedullin (porcine)
	Adrenomedullin (porcine) is a vasodilatory peptide that elicits endothelium-dependent relaxation in rat aorta at an IC50 of 2.4 nM and also induces endothelium-independent relaxation in porcine coronary arteries, with an...
TN1246	3-Deoxysappanone B		Others
	3-Deoxysappanone B has vasorelaxation effects, it can mediate endothelium- independent vasodilator action in rat thoracic aortic rings.		Others
T76421	Protein Kinase C β Peptide
	Protein Kinase C (beta) Peptide, a fragment of Protein Kinase Cβ, is associated with hyperglycemia-induced decreases in endothelium-derived nitric oxide. Inhibiting Protein Kinase Cβ forestalls the impairment of endothel...