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Pentagalloylglucose

Name: Pentagalloylglucose
Brand: TargetMol
SKU: T3794
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Penta-O-galloyl-β-D-glucose, 1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose, 1,2,3,4,6-O-Pentagalloylglucose) Copy Product Info

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Synonyms: Penta-O-galloyl-β-D-glucose, 1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose, 1,2,3,4,6-O-Pentagalloylglucose

Catalog No. T3794 Copy Product Info

Purity: 99.97%

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Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is a natural product functioning as an apoptosis and autophagy inducer. Possessing oral bioavailability, this compound exhibits diverse pharmacological effects including antiviral and antitumor activities through modulation of the GSK3β/β-catenin and p53 signaling pathways.

Cas No. 14937-32-7

Pack Size	Price	USA Stock	Global Stock
2 mg	$35	In Stock	In Stock
5 mg	$52	In Stock	In Stock
10 mg	$77	In Stock	In Stock
25 mg	$143	In Stock	In Stock
50 mg	$218	In Stock	In Stock
100 mg	$325	-	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.97%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is a natural product functioning as an apoptosis and autophagy inducer. Possessing oral bioavailability, this compound exhibits diverse pharmacological effects including antiviral and antitumor activities through modulation of the GSK3β/β-catenin and p53 signaling pathways.
Targets & IC50	HCT116 cells:1.61 μM, TE-671 cells:> 10 μg/mL (ED50), HepG2 cells:92.4 μM, HeLa cells:356.3 μM, MDA-MB-231 cells:9.12 μM, NCM460 cells:23 μg/mL, HT29 cells:28 μg/mL
In vitro	Methods: Human triple-negative breast cancer doxorubicin-resistant cells MDA-MB-231/ADR were treated with 12.5-50 μg/mL pentagalloylglucose for 24-48 h. Cell viability, apoptosis, migration, invasion, and EMT-related proteins were detected by MTT assay, Annexin V/PI staining, Transwell, and Western blot. Results: Pentagalloylglucose concentration-dependently inhibited cell viability, migration, and invasion, induced apoptosis, upregulated E-cadherin, downregulated ZEB1 and vimentin, and reversed the EMT phenotype. [1] Methods: Human colorectal cancer cells HCT116, RKO, and others were treated with various concentrations of PGG for 72 h. Cell proliferation was detected by CellTiter 96 AQueous One Solution cell viability assay. Results: PGG concentration-dependently inhibited cell viability with IC50 values of 5.4–16.9 μmol/L, and decreased total RNA m1A levels and ONECUT2 expression. [2]
In vivo	Methods: Subcutaneous xenograft tumor models of human colorectal cancer HCT116 and RKO cells, AOM/DSS-induced colorectal cancer model, and ApcMin/+ spontaneous intestinal adenoma model were established. Pentagalloylglucose (PGG) (20 mg/kg, dissolved in PBS) was administered by intraperitoneal injection 2–3 times per week. Results: Pentagalloylglucose (PGG) significantly inhibited xenograft tumor growth and intestinal tumor formation, reduced tumor cell proliferation, promoted apoptosis, and showed no obvious toxicity. [2] Methods: KC pancreatic cancer precursor lesion and KPC pancreatic ductal adenocarcinoma mouse models were used. Pentagalloylglucose (PGG) (40 mg/kg, dissolved in PBS) was administered orally once daily. Results: Pentagalloylglucose (PGG) significantly reduced the area and grade of pancreatic cancer precursor lesions, decreased Ki67 levels in PDAC tissue, and inhibited malignant tumor progression. [3]
Synonyms	Penta-O-galloyl-β-D-glucose, 1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose, 1,2,3,4,6-O-Pentagalloylglucose

Chemical Properties

Molecular Weight	940.68
Formula	C₄₁H₃₂O₂₆
Cas No.	14937-32-7
Smiles	Oc1cc(cc(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(O)c1
Relative Density.	2.05 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Store at low temperature,Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 142 mg/mL (150.95 mM), Sonication is recommended.

In Vivo Formulation

5% DMSO+95% Saline: 5 mg/mL (5.32 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0631 mL	5.3153 mL	10.6306 mL	53.1530 mL
5 mM	0.2126 mL	1.0631 mL	2.1261 mL	10.6306 mL
10 mM	0.1063 mL	0.5315 mL	1.0631 mL	5.3153 mL
20 mM	0.0532 mL	0.2658 mL	0.5315 mL	2.6577 mL
50 mM	0.0213 mL	0.1063 mL	0.2126 mL	1.0631 mL
100 mM	0.0106 mL	0.0532 mL	0.1063 mL	0.5315 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

Penta-O-galloyl-beta-D-glucosePenta-O-galloyl-b-D-glucosePentagalloylglucoseInhibitorinhibitInfluenzaVirusInfluenza Virus1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose1,2,3,4,6-Penta-O-galloyl-b-D-glucopyranose1,2,3,4,6-Pentagalloyl glucose

Related Tags: Pentagalloylglucose chemical structure | Pentagalloylglucose in vivo | Pentagalloylglucose in vitro | Pentagalloylglucose formula | Pentagalloylglucose molecular weight