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Pentagalloylglucose

Catalog No. T3794   CAS 14937-32-7
Synonyms: Penta-O-galloyl-β-D-glucose, 1,2,3,4,6-O-Pentagalloylglucose, 1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose

1, 2, 3, 4, 6-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) and gallic acid from Pistacia lentiscus have antimutagenic and antioxidant activities. 2. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose (PGG) possesses potent anti-proliferative and anti-invasive effects, it also has inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity. 3. PGG may serve as a model for the development of new types of anti-diabetic and anti-metabolic syndrome therapeutics. 4. 1, 2, 3, 4, 6-Penta- O -galloyl-β- d -glucose has vasodilatory and anti-inflammatory effects, it dilates vascular smooth muscle and suppresses the vascular inflammatory process via endothelium-dependent nitric oxide (NO)/cGMP signaling. 5. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose can decrease the level of extracellular hepatitis B virus (HBV) (IC5, 1. microg/ml) in a dose-dependent manner, it also can reduce the HBsAg level by 25% at a concentration of 4 microg/ml; the gallate structure of PGG may play a critical role in the inhibition of anti-HBV activity, suggests that PGG could be a candidate for developing an anti-HBV agent. 6. 1, 2, 3, 4, 6-Penta-O-galloyl-β-D-glucose has anti-parasitic activity, displays an EC5 value of 67 μM, at least 6.6-fold more effective than the standard drug benznidazole against trypomastigote forms of T. cruzi.

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Pentagalloylglucose Chemical Structure
Pentagalloylglucose, CAS 14937-32-7
Pack Size Availability Price/USD Quantity
5 mg In stock $ 52.00
10 mg In stock $ 77.00
25 mg In stock $ 143.00
50 mg In stock $ 218.00
100 mg In stock $ 325.00
500 mg In stock $ 789.00
1 mL * 10 mM (in DMSO) In stock $ 79.00
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Purity: 99.58%
Purity: 99.17%
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Biological Description
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Storage & Solubility Information
Description 1, 2, 3, 4, 6-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) and gallic acid from Pistacia lentiscus have antimutagenic and antioxidant activities. 2. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose (PGG) possesses potent anti-proliferative and anti-invasive effects, it also has inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity. 3. PGG may serve as a model for the development of new types of anti-diabetic and anti-metabolic syndrome therapeutics. 4. 1, 2, 3, 4, 6-Penta- O -galloyl-β- d -glucose has vasodilatory and anti-inflammatory effects, it dilates vascular smooth muscle and suppresses the vascular inflammatory process via endothelium-dependent nitric oxide (NO)/cGMP signaling. 5. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose can decrease the level of extracellular hepatitis B virus (HBV) (IC5, 1. microg/ml) in a dose-dependent manner, it also can reduce the HBsAg level by 25% at a concentration of 4 microg/ml; the gallate structure of PGG may play a critical role in the inhibition of anti-HBV activity, suggests that PGG could be a candidate for developing an anti-HBV agent. 6. 1, 2, 3, 4, 6-Penta-O-galloyl-β-D-glucose has anti-parasitic activity, displays an EC5 value of 67 μM, at least 6.6-fold more effective than the standard drug benznidazole against trypomastigote forms of T. cruzi.
Source
Synonyms Penta-O-galloyl-β-D-glucose, 1,2,3,4,6-O-Pentagalloylglucose, 1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose
Molecular Weight 940.68
Formula C41H32O26
CAS No. 14937-32-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 106.3 mM

TargetMolReferences and Literature

1. Abdelwahed A, et al. Study of antimutagenic and antioxidant activities of gallic acid and 1,2,3,4,6-pentagalloylglucose from Pistacia lentiscus. Confirmation by microarray expression profiling. Chem Biol Interact. 2007 Jan 5;165(1):1-13. 2. Kang DG, et al. Vasodilatory and anti-inflammatory effects of the 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) via a nitric oxide-cGMP pathway. Eur J Pharmacol. 2005 Nov 7;524(1-3):111-9. 3. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet[J]. Planta medica. 2019.

TargetMolCitations

1. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet. Planta Medica. 2019, 85(14/15): 1128-1135

Related compound libraries

This product is contained In the following compound libraries：
Anti-Parasitic Compound Library Antiparasitic Natural Product Library Traditional Chinese Medicine Monomer Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Tibetan medicine Compound Library Natural Product Library Saccharide and Glycoside Natural Product Library Ferroptosis Compound Library Bioactive Compound Library PBCRBS Traditional Chinese Medicine Compound Library

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Keywords

Pentagalloylglucose 14937-32-7 Microbiology/Virology Influenza Virus inhibit Penta-O-galloyl-β-D-glucose 1,2,3,4,6-Pentagalloyl glucose 1,2,3,4,6-O-Pentagalloylglucose Penta-O-galloyl-beta-D-glucose Penta-O-galloyl-b-D-glucose 1,2,3,4,6-Penta-O-galloyl-b-D-glucopyranose Inhibitor 1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose 1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose inhibitor

 

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