Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3-Deoxysappanone B has vasorelaxation effects, it can mediate endothelium- independent vasodilator action in rat thoracic aortic rings.
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5 mg | Inquiry | $ 590.00 | |
1 mL * 10 mM (in DMSO) | Inquiry | $ 610.00 |
Description | 3-Deoxysappanone B has vasorelaxation effects, it can mediate endothelium- independent vasodilator action in rat thoracic aortic rings. |
In vitro | The tension of rat thoracic aorta rings was used to evaluated the vasorelaxant activities of four homoisoflavonoids, brazlin (1), (E)-3-(3,4-dihydroxybenzylidene)-7-hydroxychroman-4-one (2), sappanone B (3), 3-Deoxysappanone B (4). Cumulative addition of homoisoflavonoids (2, 3 and 4) (50-1000 micromol x L(-1)) exhibited an acute relaxation either in endothelium-intact or endothelium-denuded rings in a concentration-dependent manner. However, this relaxation was significantly inhibited in endothelium-denuded condition and in the presence of endothelial nitric oxide synthase (eNOS) inhibitor, N(W)-nitro-L-arginine methyl ester (L-NNA, 100 micromol x L(-1)), and a soluble guanylate cylcase (sGC) inhibitor, methylene blue (MB, 10 micromol x L(-1)) when addition of variation homoisoflavonoids brazlin (1) (50-1000 micromol x L(-1)). |
Source |
Molecular Weight | 286.28 |
Formula | C16H14O5 |
CAS No. | 113122-54-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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3-Deoxysappanone B 113122-54-6 Others 3Deoxysappanone B 3 Deoxysappanone B inhibitor inhibit