deficits — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2301	SB 202190	FHPI,SB202190	Apoptosis , p38 MAPK , Autophagy
	SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably. SB 202190 has antitumor activity and also induces the differentiation of human embryonic stem cells i...		Apoptosis , p38 MAPK , Autophagy
T9317	TAK-041	NBI-1065846	GPR
	TAK-041 (NBI-1065846) is a potent and selective GPR139 agonist.		GPR
T22103	ML-193	CID 1261822	Cannabinoid Receptor
	ML-193 (CID 1261822) is a potent and selective GPR55 antagonist( IC50 : 221 nM). It shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2, and can improve the motor and the sensorimotor deficits of Parkin...		Cannabinoid Receptor
T12165	NAChR agonist 1	DUN71755	AChR
	nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.		AChR
T4576	Perospirone	Lullan	Dopamine Receptor , 5-HT Receptor
	Perospirone (Lullan) is an antagonist of serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.		Dopamine Receptor , 5-HT Receptor
T4074	GSK-872	GSK872,GSK'872,GSK2399872A	RIP kinase
	GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).		RIP kinase
T22016	A-582941 dihydrochloride	A 582941	5-HT Receptor , AChR
	A-582941 dihydrochloride (A 582941) is a Selective agonist of α7 nAChR partial		5-HT Receptor , AChR
T2306	Brexpiprazole	OPC-34712	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
	Brexpiprazole (OPC-34712) is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors.		Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
T8690	Brexpiprazole HCl	OPC 34712 dihydrochloride	Others
	Brexpiprazole HCl (OPC 34712 dihydrochloride) is a new antipsychotic drug.		Others
T23145	PHA 543613		Others , AChR
	PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.		Others , AChR
T22378	Nilotinib hydrochloride	AMN-107 HCl	Bcr-Abl , Autophagy
	Nilotinib hydrochloride(AMN-107 HCl) is an orally available Bcr-Abl tyrosine kinase inhibitor with antitumor activity for modulation of neuroinflammation and cognitive deficits, and may be used in studies of chronic myel...		Bcr-Abl , Autophagy
T8448	ZSET1446	ZSET-1446,ST-101	Calcium Channel , AChR
	ZSET1446 (ST-101) is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models.		Calcium Channel , AChR
T24184	Itasetron	DAU6215CL,UNII-00S0D0OEKR,U-98079A,U 98079A,DAU 6215CL	5-HT Receptor
	Itasetron (U 98079A) is a 5-hydroxytryptamine 3-receptor antagonist used to prevent age-related memory deficits in rats.Itasetron's antiemetic activity in animal models of cancer chemotherapy and radiation therapy may be...		5-HT Receptor
T23331	SC 51089	SC 51089 free base	Prostaglandin Receptor
	SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and anti-injury activity that ameliorates motor deficits and rescues memory loss in the R6/1 mouse model...		Prostaglandin Receptor
T61564	PF-03463275	PF-3463275	GlyT
	PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS permeability and may be used to ameliorate cognitive defici...		GlyT
T60739L	Y13g dihydrochloride	Y13g 2HCl(T60739 Free base)	IL Receptor , AChE
	Y13g dihydrochloride is a potent inhibitor of interleukin 6 (IL-6) and acetylcholinesterase (AChE) (both targets of Alzheimer's disease (AD) progression are related). Y13g dihydrochloride reverses STZ-induced memory defi...		IL Receptor , AChE
T34081	Piromelatine	NEU-P-11,NEU-P 11,NEU-P11	P2X Receptor , 5-HT Receptor , MT Receptor , Sodium Channel , TRP/TRPV Channel
	Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ...
T4364	Aftin-4	Aftin 4,Aftin4	Beta Amyloid , Gamma-secretase
	Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus...		Beta Amyloid , Gamma-secretase
T67913	(-)-GSK598809 hydrochloride
	(-)-GSK598809 hydrochloride is the isomer of GSK598809. GSK598809 is a selective antagonist of the dopamine D3 receptor (DRD3), which is a neural response that selectively enhances reward anticipation in drug and alcohol...
T14305	Apicidin	OSI 2040	Apoptosis , HDAC , Autophagy
	Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic activity and antiproliferative activity.Apicidin attenuates memory deficits, inhibits cell growth and proliferation, and induces apoptosis ...		Apoptosis , HDAC , Autophagy