keep away from direct sunlight,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's disease R6/1 mouse model .
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 293.00 | |
5 mg | In stock | $ 722.00 | |
10 mg | In stock | $ 987.00 | |
25 mg | In stock | $ 1,520.00 | |
50 mg | In stock | $ 1,980.00 | |
100 mg | In stock | $ 2,500.00 |
Description | SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's disease R6/1 mouse model . |
Targets&IC50 | EP1:1.3 μM (Ki), 11.2 μM (Ki):EP3, FP:61.1 μM (Ki), TP:11.2 μM (Ki) |
In vivo | In the R6/1 mouse model of Huntington's disease (HD), treatment with SC 51089 (40 μg/kg/day; i.p.) for 28 days improved motor coordination and balance deficits, rescued long-term memory loss, as well as improved the expression of specific synaptic markers and reduced the number of intranuclear inclusions of huntingtin protein in the striatum and hippocampus[3]. |
Synonyms | SC 51089 free base |
Molecular Weight | 459.33 |
Formula | C22H20Cl2N4O3 |
CAS No. | 146033-02-5 |
keep away from direct sunlight,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (189.19 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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SC 51089 146033-02-5 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor SC-51089 SC51089 SC 51089 free base inhibitor inhibit